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Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans
BackgroundLittle is known about the role of amino acids in cellular signaling pathways, especially as it pertains to pathways that regulate the rate of aging. However, it has been shown thatExpand
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D-beta-hydroxybutyrate extends lifespan in C. elegans
The ketone body beta-hydroxybutyrate (βHB) is a histone deacetylase (HDAC) inhibitor and has been shown to be protective in many disease models, but its effects on aging are not well studied.Expand
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Malate and Fumarate Extend Lifespan in Caenorhabditis elegans
Malate, the tricarboxylic acid (TCA) cycle metabolite, increased lifespan and thermotolerance in the nematode C. elegans. Malate can be synthesized from fumarate by the enzyme fumarase and furtherExpand
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