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Schedule-induced polydipsia was used to determine the effects of selective serotonin re-uptake inhibitors on adjunctive water consumption. Polydipsia was induced in food deprived rats by exposure to a fixed time feeding schedule (FT = 60 s) for 150 min per day for 22 days. Selected polydipsic rats consumed 3-4 times greater volume of water compared to food(More)
Injections of horseradish peroxidase (HRP) into the right or left ovary of the rat produced labeling of perikarya in both nodose ganglia and ipsilateral dorsal root ganglia (DRGs) from T10 to L2. The greatest concentration of labeled cells was in T13 and L1, DRGs. It is suggested that visceral afferent fibers from the ovary may mediate visceral reflexes(More)
The availability of an animal model for obsessive-compulsive disorder (OCD) is necessary for the development of novel pharmacological treatments. To be useful, the model must be predictive of clinical performance, possess characteristic criteria and distinguish anti-OCD from antidepressant compounds. Due to the lack of OCD models useful for drug discovery,(More)
The aim of the present paper is to report on the adrenergic and serotonergic effects of besipirdine (HP 749) in vivo and to discuss its potential use in the treatment of obsessive compulsive disorder. Besipirdine inhibited biogenic amine uptake in vitro. It prevented tetrabenazine-induced ptosis in mice and potentiated the 5-hydroxytryptophan-induced(More)
We examined the effects of beta-amyloid1-40 (A beta 1-40) on the electrically stimulated release of [3H]norepinephrine (NE) and the potassium chloride (KCl)-evoked increases in intrasynaptosomal calcium ([Ca2+]i) from rat brain cortical slices and synaptosomes, respectively. The results show that 3nM A beta 1-40 decreased electrically stimulated [3H]NE(More)
Abeta1-40 (20 microM) has been reported to selectively inhibit Na+/K+-ATPase activity in rat primary hippocampal cultures after 2-6 days of exposure. We expanded these studies to include Abeta's effects on Na+/K+-ATPase activity in rat primary cortical cultures and hippocampal slices, and we correlated these effects with estimates of cell survival in rat(More)
In this paper we show how the alleged relationship between AI and Law exhibits an example of reductions of a relevant kind. We put forward a methodological approach, based on the key epistemological concept of reduction, to the understanding, explanation and conceptualisation of phenomena concerning legal systems. This approach is appropriate as a(More)
Examination of HP 184, [N-n-propyl)-N-(3-fluoro-4-pyridinyl) -1H-3-methylindodel-1-amine hydrochloride], in a variety of tests for serotonergic activity revealed some unique properties of this compound. We report here that 100 microM HP 184 enhanced spontaneous release of [3H]serotonin (5-HT) from rat hippocampal slices. This release was independent of the(More)
The cholinergic hypothesis of Alzheimer's disease (AD) has strongly influenced research on learning and memory over the last decade. However, there has been limited success treating AD dementia with cholinomimetics. Furthermore, there are indications that other neurotransmitter systems affected by this disease may be involved in cognitive processes. Animal(More)
1. Besipirdine (HP 749) is a compound undergoing clinical trials for efficacy in treating Alzheimer's disease. Among other pharmacological effects, besipirdine inhibits voltage-dependent sodium and potassium channels. This paper presents a pharmacological study of the interaction of besipirdine with voltage-dependent sodium channels. 2. Besipirdine(More)