Clara Nguyen

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OBJECTIVE Fractures occurring at the site of a tophus have rarely been described in gout. In this paper we review the occurrence, clinical features, and outcome of fractures in tophaceous gout. METHOD A PubMed search was conducted to identify the relevant literature, following our experience with two patients who developed tophaceous fractures after minor(More)
OBJECTIVE Basic calcium phosphate (BCP) crystals, including octacalcium phosphate (OCP), carbonated-apatite (CA) and hydroxyapatite (HA) crystals are associated with destructive forms of osteoarthritis. Mechanisms of BCP-induced cartilage breakdown remain incompletely understood. We assessed the ability of BCP to induce changes in intracellular calcium(More)
Crinophagy is a well-described ultraphysiological phenomenon encountered in a variety of cells and tissues. This process reflects a form of autophagy in which degradation of excess or nonfunctional cellular constituents occurs, specifically of neuroendocrine granules. The diagnostic ultrastructural features are the identification of neuroendocrine granules(More)
We previously described myopathy with crystalloid, “hexagonally cross-linked tubular arrays” (HCLTA) in patients with a mild proximal limb girdle myopathy [1, 5]. We are now reporting immunohistochemical and molecular studies on another patient with such inclusions. A 45-year-old male underwent open quadriceps biopsy for slight muscle pain around knees and(More)
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