Clara De Palma

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Nitric oxide is a short-lived intracellular and intercellular messenger. The first realisation that nitric oxide is important in physiology occurred in 1987 when its identity with the endothelium-derived relaxing factor was discovered. Subsequent studies have shown that nitric oxide possesses a number of physiological functions that are essential not only(More)
Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in cell survival and death. Autophagy is regulated at various levels and novel modulators of its function are being continuously identified. An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid Sphingomyelinase(More)
Skeletal muscle tissue is composed of multinucleated fi bers that arise at defi ned periods of embryogenesis from fusion of myoblasts (Buckingham et al., 2003). In particular, embryonic and fetal myoblasts, originating from different waves of myoblasts (Cusella-De Angelis et al., 1994; Relaix et al., 2005), give rise to primary (at about embryonic day [E](More)
INTRODUCTION Early onset placenta Preeclampsia (ePE) with Intrauterine Growth Restriction (IUGR) is associated with insufficient placental function, leading to decreased nutrient and oxygen (O2) availability for the fetus [1]. Mitochondria (mt) are the cell energy producers. Mt dysfunctions could be involved in altered placental metabolism leading to ePE(More)
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