Claire Toffano-Nioche

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This paper presents a computational model of Parkinson's Disease (PD) symptoms. Based on psychophysiological data, the underlying system (Guided Propagation Network) implements coincidence detection between internal flows and stimuli, and can be dynamically controlled for representing the action of neuromodulators such as dopamine (DA). By modelling the DA(More)
BACKGROUND Meiotic exchanges are non-uniformly distributed across the genome of most studied organisms. This uneven distribution suggests that recombination is initiated by specific signals and/or regulations. Some of these signals were recently identified in humans and mice. However, it is unclear whether or not sequence signals are also involved in(More)
L'annotation d'une protéine consiste, entre autres, à lui attribuer une classe dans une hiérarchie fonctionnelle. Celle-ci permet d'organiser les connais-sances biologiques et d'utiliser un vocabulaire contrôlé. Pour estimer la perti-nence des annotations, des mesures telles que la précision, le rappel, la spécifi-cité et le Fscore sont utilisées. Cependant(More)
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