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CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells.
Neisseria meningitidis is one of the leading causes of bacterial meningitis and septicemia in children. Vaccines containing the purified polysaccharide capsule from the organism, a T cell-independent… Expand
Serogroup C meningococcal glycoconjugate vaccine in adolescents: persistence of bactericidal antibodies and kinetics of the immune response to a booster vaccine more than 3 years after immunization.
- M. Snape, D. Kelly, +7 authors A. Pollard
- Clinical infectious diseases : an official…
- 1 December 2006
BACKGROUND The persistence of protection from meningococcal disease following immunization with serogroup C meningococcal (MenC) glycoconjugate vaccines in infancy is short-lived. The duration of… Expand
antigen-specific memory B cells polysaccharide, but not the native polysaccharide, induces persistent CRM197-conjugated serogroup C meningococcal capsular
Running Title: Meningococcal conjugate vaccine induces persistent memory B-cells Subject : Immunobiology