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- Elena Goicoechea de Jorge, Claire Louise Harris, +7 authors Santiago RodrÃguez de Córdoba
- Proceedings of the National Academy of Sciences…
- 2007
Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children. Mutations in one or more genes encoding complement-regulatory proteins have been reported in approximately… (More)
- Mark S Cragg, Elisa S. Jansen, Michele D Cook, Claire Louise Harris, Andreas Strasser, Clare L Scott
- The Journal of clinical investigation
- 2008
B-RAF is frequently mutated in solid tumors, resulting in activation of the MEK/ERK signaling pathway and ultimately tumor cell growth and survival. MEK inhibition in these cells results in cell… (More)
- Elena Goicoechea de Jorge, Joseph J. E. Caesar, +8 authors Susan M Lea
- Proceedings of the National Academy of Sciences…
- 2013
The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the… (More)
- Yoshinobu Maeda, R. T. Watanabe, +4 authors Taroh Kinoshita
- The EMBO journal
- 2001
Glycosylphosphatidylinositol (GPI) acts as a membrane anchor of many cell surface proteins. Its structure and biosynthetic pathway are generally conserved among eukaryotic organisms, with a number of… (More)
- Matthew C Pickering, Vivette D D'agati, +32 authors H Terence Cook
- Kidney international
- 2013
C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition. In… (More)
- AgustÃn Tortajada, Tamara Montes, Rubén MartÃnez-Barricarte, Bryan Morgan, Claire Louise Harris, Santiago RodrÃguez de Córdoba
- Human molecular genetics
- 2009
Mutations and polymorphisms in the gene encoding factor H (CFH) have been associated with atypical haemolytic uraemic syndrome, dense deposit disease and age-related macular degeneration. The… (More)
- AgustÃn Tortajada, Hugo Yébenes, +13 authors Santiago RodrÃguez de Córdoba
- The Journal of clinical investigation
- 2013
C3 glomerulopathies (C3G) are a group of severe renal diseases with distinct patterns of glomerular inflammation and C3 deposition caused by complement dysregulation. Here we report the… (More)
- Richard J. H. Smith, Claire Louise Harris, Matthew C Pickering
- Molecular immunology
- 2011
Dense deposit disease (DDD) is an orphan disease that primarily affects children and young adults without sexual predilection. Studies of its pathophysiology have shown conclusively that it is caused… (More)
- MartÃn Alcorlo, Ruben Martinez-Barricarte, +6 authors Oscar Llorca
- Proceedings of the National Academy of Sciences…
- 2011
Activation of C3, deposition of C3b on the target surface, and subsequent amplification by formation of a C3-cleaving enzyme (C3-convertase; C3bBb) triggers the effector functions of complement that… (More)
- Gopal Thinakaran, Claire Louise Harris, +5 authors Sangram S. Sisodia
- The Journal of biological chemistry
- 1997
Mutations in two related genes, PS1 and PS2, account for the majority of early onset cases of familial Alzheimer's disease. PS1 and PS2 are homologous polytopic membrane proteins that are processed… (More)