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PURPOSE Acute caffeine exposure has proconvulsant effects and worsens epileptic and ischemic neuronal damage. Surprisingly, prolonged caffeine exposure decreases the susceptibility to seizures andContinue Reading
  • Claire Leroy, Catherine Roch, Estelle Koning, Izzie Namer, Astrid Nehlig
  • Medicine, Biology
  • Experimental Neurology
  • 1 August 2003
  • Lithium-pilocarpine-induced status epilepticus (SE) leads to the genesis of massive neuronal loss in adult rats and to a lesser extent in P21 rats. Neuronal damage occurs mainly via a process ofContinue Reading
  • Claire Leroy, Karin Pierre, Ian A. Simpson, Luc Pellerin, Astrid Nehlig
  • Biology, Medicine
  • Neurobiology of Disease
  • 1 September 2011
  • The lithium-pilocarpine model mimics most features of human temporal lobe epilepsy. Following our prior studies of cerebral metabolic changes, here we explored the expression of transporters forContinue Reading