Claire Leduc

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In the last decade, the Cree Nation of Eeyou Istchee has witnessed a 150% increase in the prevalence of Type II Diabetes (T2D) for people aged over 20 years. Clinical intervention using conventional therapeutic methods has yielded only a limited success within this population. An ethnobotanical survey was carried out to identify potentially antidiabetic(More)
"Replicative stress" is one of the main factors underlying neoplasia from its early stages. Genes involved in DNA synthesis may therefore represent an underexplored source of potential prognostic markers for cancer. To this aim, we generated gene expression profiles from two independent cohorts (France, n=206; United Kingdom, n=117) of patients with(More)
Simulators for dynamic systems are now widely used in various application areas and raise the need for effective and accurate flow visualization techniques. Animation allows us to depict direction, orientation, and velocity of a vector field accurately. We extend a former proposal for a new approach to produce perfectly cyclic and variable-speed animations(More)
The transformation/transcription domain-associated protein (TRRAP) is a common component of many histone acetyltransferase (HAT) complexes. Targeted-deletion of the Trrap gene led to early embryonic lethality and revealed a critical function of TRRAP in cell proliferation. Here, we investigate the function of TRRAP in murine B cells. To this end, we ablated(More)
CONTEXT Clinical clerkships in medical colleges are increasingly relying on teaching by community physicians in ambulatory clinics. OBJECTIVES The aim of the study was to determine the attitudes and perceptions of community physicians towards teaching medical students at their clinics. METHODS A focus group discussion with 14 and a survey questionnaire(More)
Class switch recombination (CSR) is mediated by G-rich tandem repeated sequences termed switch regions. Transcription of switch regions generates single-stranded R loops that provide substrates for activation-induced cytidine deaminase. Mice deficient in MSH2 have a mild defect in CSR and analysis of their switch junctions has led to a model in which MSH2(More)
Developing lymphocytes somatically diversify their antigen-receptor loci through V(D)J recombination. The process is associated with allelic exclusion, which results in monoallelic expression of an antigen receptor locus. Various cis-regulatory elements control V(D)J recombination in a developmentally regulated manner, but their role in allelic exclusion is(More)
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