Claire L. Vale

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BACKGROUND The National Cancer Institute (USA) alert in February 1999 stated that concomitant chemoradiotherapy should be considered for all patients with cervical cancer, based on evidence from five randomised controlled trials (RCTs). OBJECTIVES To review all known RCTs comparing concomitant chemotherapy and radiation therapy with radiotherapy for(More)
BACKGROUND Results from large randomised controlled trials combining docetaxel or bisphosphonates with standard of care in hormone-sensitive prostate cancer have emerged. In order to investigate the effects of these therapies and to respond to emerging evidence, we aimed to systematically review all relevant trials using a framework for adaptive(More)
OBJECTIVE To establish the extent to which systematic reviews and meta-analyses of individual participant data (IPD) are being used to inform the recommendations included in published clinical guidelines. DESIGN Descriptive study. SETTING Database maintained by the Cochrane IPD Meta-analysis Methods Group, supplemented by records of published IPD(More)
BACKGROUND A prior systematic review found that giving neoadjuvant chemotherapy before surgery improved survival compared with radiotherapy. However, the role of neoadjuvant chemotherapy followed by surgery versus surgery alone is still unclear. OBJECTIVES To assess the role of neoadjuvant chemotherapy in women with early or locally advanced cervical(More)
BACKGROUND There is a need to synthesise the results of numerous randomised controlled trials evaluating the addition of therapies to androgen deprivation therapy (ADT) for men with metastatic hormone-sensitive prostate cancer (mHSPC). This systematic review aims to assess the effects of adding abiraterone acetate plus prednisone/prednisolone (AAP) to ADT.(More)
OBJECTIVE To explore the strategies used to improve retention in primary care randomised trials. DESIGN Qualitative in-depth interviews and thematic analysis. PARTICIPANTS 29 UK primary care chief and principal investigators, trial managers and research nurses. METHODS In-depth face-to-face interviews. RESULTS Primary care researchers use incentive(More)
OBJECTIVE To evaluate the reliability of risk of bias assessments based on published trial reports, for determining trial inclusion in meta-analyses. DESIGN Reliability evaluation of risk of bias assessments. DATA SOURCES 13 published individual participant data (IPD) meta-analyses in cancer were used to source 95 randomised controlled trials. REVIEW(More)
Guidance concerning tyrosine kinase inhibitors (TKIs) for patients with wild type epidermal growth factor receptor (EGFR) and advanced non-small-cell lung cancer (NSCLC) after first-line treatment is unclear. We assessed the effect of TKIs as second-line therapy and maintenance therapy after first-line chemotherapy in two systematic reviews and(More)
BACKGROUND Providing evidence of impact highlights the benefits of medical research to society. Such evidence is increasingly requested by research funders and commonly relies on citation analysis. However, other indicators may be more informative. Although frameworks to demonstrate the impact of clinical research have been reported, no complementary(More)