Little attention has been paid to the influence of the repro ductive condition of the rat at the time of irradiation upon X-ray-induced mammary carcinogenesis. At 12 weeks of age, 160 virgin female Sprague-Dawley rats were mated, and an other 140 were maintained as virgins. On Days 14 to 16 of pregnancy, 36 mated females and 40 virgins were whole-body… (More)
1781 Benzo(a)pyrene Metabolism In Bovine Aortic Endo thellal and Bovine Lung Fibroblast-like Cell Cultures.
Both radiation and diethylstilbestrol (DES) are carcinogens for the mammary gland of ACI female rats. When DES is given at about the same time as radiation, DES and radiation interact in a synergistic fashion particularly in regard to the number of mammary adenocarcinomas per rat. We have studied the effect of increasing the time interval between radiation… (More)