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Reconstruction plates permit contouring to the irregular anatomic shape of the clavicle. This study evaluated the biomechanical stability of locking and nonlocking clavicle reconstruction plates for treating midshaft, transverse fractures, comparing anterior-inferior to superior plate position. Twenty-four synthetic clavicles with mid-shaft fractures were(More)
Human pluripotent stem cell-derived cardiomyocytes (hPS-CM) may offer a number of advantages over previous cardiac models, however, questions of their immaturity complicate their adoption as a new in vitro model. hPS-CM differ from adult cardiomyocytes with respect to structure, proliferation, metabolism and electrophysiology, better approximating fetal(More)
STUDY DESIGN In vitro biomechanical investigation. OBJECTIVE To evaluate differences in biomechanical stability of vertebral compression fractures repaired using balloon kyphoplasty versus a titanium mesh implant. SUMMARY OF BACKGROUND DATA Vertebral compression fractures may be stabilized using an expandable balloon followed by cement injection. There(More)
STUDY DESIGN In vitro biomechanical investigation using human cadaveric vertebral bodies. OBJECTIVE To evaluate differences in biomechanical stability of vertebral compression fractures (VCFs) repaired using an expandable titanium mesh implant, with and without cement, as compared with standard balloon kyphoplasty. SUMMARY OF BACKGROUND DATA Vertebral(More)
The development of the mammary gland is unique: the final stages of development occur postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of the female, the mammary gland can undergo many rounds of expansion and proliferation. The mammary gland thus provides an excellent model for studying the 'stem/progenitor' cells(More)
BACKGROUND The most common position of malreduced type III supracondylar humerus (SCH) fractures is internal rotation and medial collapse of the distal fragment. The purpose of this study was to determine the effect of SCH fracture rotational deformity on stability with various pin configurations. Specifically, is the biomechanical stability lost when an(More)
PURPOSE Our purpose was to investigate the importance of medial-row knot tying to mechanical stability in a double-row rotator cuff repair by comparing a knotless construct with transtendon anchor passage versus a similar construct implementing medial knots. METHODS A standard defect was created in the infraspinatus tendons of 14 bovine humeri. All(More)
Decellularization of xenogeneic hearts offers an acellular, naturally occurring, 3D scaffold that may aid in the development of an engineered human heart tissue. However, decellularization impacts the structural and mechanical properties of the extracellular matrix (ECM), which can strongly influence a cell response during recellularization. We hypothesized(More)
OBJECTIVES The purpose of this study was to gain insight into the effect of plate location and screw type for fixation of extra-articular distal radius fractures with dorsal comminution (Orthopaedic Trauma Association Type 23-A3.2). METHODS Sixteen pairs of cadaver radii were randomized to four plating configurations: dorsal locking, dorsal nonlocking,(More)
Image correlation spectroscopy (ICS) is a powerful technique for detecting arrangement of fluorophores in images. This tutorial gives background into the mathematical underpinnings of ICS, specifically image autocorrelation. The effects of various artifacts and image processing steps, including background subtraction, noise, and image morphology were(More)