Claire Guiol

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The effects of apomorphine on blood pressure and heart rate were studied in normotensive chloralose anaesthetized dogs. Intravenous apomorphine (200 micrograms/kg) induced both a marked decrease of blood pressure and an increase in heart rate. These two cardiovascular responses to intravenous apomorphine were suppressed by haloperidol (1 mg/kg i.v.) or(More)
The effects of central (intracisternal: i.c.) and peripheral (intravenous: i.v.) administration of apomorphine (200 micrograms/kg) were compared in chloralose anaesthetized dogs. I.v. or i.c. apomorphine induced a decrease in blood pressure (BP) and an increase in heart rate (HR). However, the decrease in BP was more marked after i.c. route. This effect was(More)
Adenosine is an ATP derivative that is implicated in a lot of cardiovascular and neurological diseases including neurocardiogenic syncope [1-3], coronary artery diseases [4,5], neuropathic pain [6], septic shock [7] and severe systemic inflammatory response [8]. Thus, measurig adenosine in blood may be helpful for some pathologies. As example measuring(More)
The pharmacological effects of the novel fluoroquinolone 7-(1R,4R-2,5-diazebicyclo[2.2.1]heptan-2-yl)-1-(1,1-dimethyl )ethyl-6-fluoro - 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (BMY-40062, CAS 116143-32-9) on central nervous system were investigated in mice and rats, in comparison in some cases with those of reference quinolones. BMY-40062(More)
The renal effects of clonidine (100 and 500 micrograms/kg s.c.) during acute hypobaric pressure breathing (i.e. a protocol which induces an increase in intrathoracic blood volume) were studied in normal and diabetes insipidus rats. In normal rats, clonidine enhanced the increase in urine flow and urea concentration elicited by hypobaric breathing without(More)
A series of novel chiral 7-(1-, 3-, 4-, and 6-methyl-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-substituted naphthyridines has been prepared with the aim of obtaining good in vitro and in vivo antibacterial agents with a decrease of the pseudoallergic type reaction when compared to that observed with(More)
The effects of naloxone (2 and 10 mg kg-1 s.c.) were compared in several kinds of experimental polyuria: alcohol- or water-loaded rats and Brattleboro rats (i.e. animals with congenital lack of vasopressin). In normal rats, both water and alcohol increased urine flow and decreased urinary osmolality. Alcohol induced a more marked diuretic response than(More)
The antinociceptive effects and the plasma levels (evaluated by high liquid pressure chromatography) of clomipramine during a subchronic (5 days) treatment were studied in rats using the Nilsen's test. Clomipramine (10, 20, 30 and 40 mg/kg administered by mouth) showed a clear dose-dependent analgesic effect. The study of the partial correlation(More)
Chronic measurements of systemic arterial blood pressure and heart rate via a chronically implanted telemetric transmitter in unrestrained rats, was validated in a three-phase study. In the first part, week-to-week variability of systolic, diastolic, and mean arterial pressures, and heart rate was found to be minimal over the course of nine weeks. In the(More)
1. The effects of two doses of clonidine (100 and 500 micrograms/kg sc) were compared on several types of experimentally induced diuresis (total value during 4 hours): alcohol or water loaded rats and Brattleboro rats (i.e. animals with congenital lack of vasopressin). 2. The two doses of clonidine alone increased the values of urine flow (fig. 1 and 3). 3.(More)