Claire C. Gianna-Poulin

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To investigate the neural mechanisms that humans use to process the ambiguous force measured by the otolith organs, we measured vestibuloocular reflexes (VORs) and perceptions of tilt and translation. One primary goal was to determine if the same, or different, mechanisms contribute to vestibular perception and action. We used motion paradigms that provided(More)
To compare and contrast the neural mechanisms that contribute to vestibular perception and action, we measured vestibuloocular reflexes (VOR) and perceptions of tilt and translation. We took advantage of the well-known ambiguity that the otolith organs respond to both linear acceleration and tilt with respect to gravity and investigated the mechanisms by(More)
Acknowledgments: Authors thank Tom Bennett and Valerie Stallings for their technical contributions, Margaret Marsden and Patty Cunningham for their administrative assistance, and Drs. Lionel Zupan and Rick Lewis for commenting on early versions of the manuscript. Experiments were performed at the Legacy Neurotology Research Laboratory. ABSTRACT To(More)
We investigated how the nervous system processes ambiguous cues from the otolith organs by measuring roll tilt perception elicited by two motion paradigms. In one paradigm (tilt), eight subjects were sinusoidally tilted in roll with the axis of rotation near ear level. Stimulus frequencies ranged from 0.005 to 0.7 Hz, and the peak amplitude of tilt was 20(More)
OBJECTIVE Determine whether subjects with documented vestibular ototoxicity recover vestibular function and, if so, investigate the recovery dynamics. STUDY DESIGN Prospective and retrospective reviews and repeated measures. SETTING Clinical research and technology center. SUBJECTS Twenty-eight subjects who received vestibulotoxic medications were(More)
A caloric stimulus evokes primarily a horizontal vestibulo-ocular reflex (VOR) when subjects are in a supine or prone orientation with the horizontal semicircular canal plane oriented vertically. In both monkeys and humans, the magnitude of VOR eye movements is greater in the supine than in the prone orientation, indicating that some factor or factors,(More)
Controversy remains about the linearity of the interaction between horizontal semicircular canal and otolith organ vestibulo-ocular reflexes (VORs) in the generation of horizontal eye movements during head movements including both rotational and translational components. We used three eccentric rotation techniques to investigate this interaction in human(More)
In healthy subjects, head tilt upon cessation of a constant-velocity yaw head rotation shortens the duration of postrotatory nystagmus. The presumed mechanism for this effect is that the velocity storage of horizontal semicircular canal inputs is being discharged by otolith organ inputs which signal a constant yaw head position when the head longitudinal(More)
Two studies explored 1) the effect of instruction set upon the well known "dumping" of the vestibulo-ocular (VOR) post-rotatory nystagmus long time constant (TC) and 2) the effect of imaginary earth-fixed targets on postural control. Imaginary targets do not produce dumping and do not improve postural stability, with or without pitch head movements.
High-velocity rotational stimuli have the potential to improve the diagnostic capabilities of clinical rotation testing by revealing nonlinear vestibulo-ocular reflex (VOR) responses that are indicative of asymmetric vestibular function. However, eye movements evoked by high-velocity rotations often are inconsistent over time and therefore do not yield(More)