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To investigate the neural mechanisms that humans use to process the ambiguous force measured by the otolith organs, we measured vestibuloocular reflexes (VORs) and perceptions of tilt and translation. One primary goal was to determine if the same, or different, mechanisms contribute to vestibular perception and action. We used motion paradigms that provided(More)
To compare and contrast the neural mechanisms that contribute to vestibular perception and action, we measured vestibuloocular reflexes (VOR) and perceptions of tilt and translation. We took advantage of the well-known ambiguity that the otolith organs respond to both linear acceleration and tilt with respect to gravity and investigated the mechanisms by(More)
Acknowledgments: Authors thank Tom Bennett and Valerie Stallings for their technical contributions, Margaret Marsden and Patty Cunningham for their administrative assistance, and Drs. Lionel Zupan and Rick Lewis for commenting on early versions of the manuscript. Experiments were performed at the Legacy Neurotology Research Laboratory. ABSTRACT To(More)
We investigated how the nervous system processes ambiguous cues from the otolith organs by measuring roll tilt perception elicited by two motion paradigms. In one paradigm (tilt), eight subjects were sinusoidally tilted in roll with the axis of rotation near ear level. Stimulus frequencies ranged from 0.005 to 0.7 Hz, and the peak amplitude of tilt was 20(More)
A caloric stimulus evokes primarily a horizontal vestibulo-ocular reflex (VOR) when subjects are in a supine or prone orientation with the horizontal semicircular canal plane oriented vertically. In both monkeys and humans, the magnitude of VOR eye movements is greater in the supine than in the prone orientation, indicating that some factor or factors,(More)
OBJECTIVE Determine whether subjects with documented vestibular ototoxicity recover vestibular function and, if so, investigate the recovery dynamics. STUDY DESIGN Prospective and retrospective reviews and repeated measures. SETTING Clinical research and technology center. SUBJECTS Twenty-eight subjects who received vestibulotoxic medications were(More)
In healthy subjects, head tilt upon cessation of a constant-velocity yaw head rotation shortens the duration of postrotatory nystagmus. The presumed mechanism for this effect is that the velocity storage of horizontal semicircular canal inputs is being discharged by otolith organ inputs which signal a constant yaw head position when the head longitudinal(More)
High-velocity rotational stimuli have the potential to improve the diagnostic capabilities of clinical rotation testing by revealing nonlinear vestibulo-ocular reflex (VOR) responses that are indicative of asymmetric vestibular function. However, eye movements evoked by high-velocity rotations often are inconsistent over time and therefore do not yield(More)
OBJECTIVE To investigate the effect of imagining a fixed spatial reference on balance control. MATERIAL AND METHODS Twenty-one healthy subjects were asked to remain as stable as possible while standing on a sway-referenced platform (NeuroCom Equitest posturography system). Subjects were instructed to keep their eyes open in the dark and to either look far(More)
This study assessed the eye movement responses to active head rotation in six subjects with complete unilateral vestibular loss (UVL), five subjects with posterior canal plugging (PCP) and age- and sex-matched normal subjects. Subjects performed head rotations in the pitch and yaw planes at frequencies ranging from 2 to 6 Hz, while looking at an earth-fixed(More)