Claire Blight

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OBJECTIVE The study was undertaken to determine the risks of adverse obstetric outcomes in pregnant women with unexplained elevations of maternal serum alpha-fetoprotein (MSAFP) and/or human chorionic gonadotropin (hCG) and to determine whether these risks vary by prepregnancy risk status. STUDY DESIGN All women who underwent double-marker screening(More)
We reviewed the available molecular cytogenetic techniques and their potential use in prenatal diagnosis of fetuses with multiple congenital anomalies and a "normal" standard chromosomal karyotype. We searched Medline to identify reports published after 1995 that were related to molecular prenatal diagnosis. After review, we reached the following(More)
OBJECTIVE To review the techniques and indications of preimplantation genetic testing, including preimplantation genetic diagnosis and screening. OPTIONS Limited to an introductory discussion about the genetic aspects of preimplantation reproductive techniques. OUTCOMES This update does not discuss in detail the adverse outcomes that have been recorded(More)
OBJECTIVE To review the molecular genetic techniques currently available for rapid prenatal diagnosis of fetal aneuploidy, as well as those still under investigation. OPTIONS Limited to introductory discussion of rapid aneuploidy detection methods. EVIDENCE Medline was searched for articles related to the topic that were published after 1992. This(More)
Objective: To provide information to genetic counsellors, midwives, nurses, and physicians who are involved in the prenatal care of women dealing with prenatally diagnosed isolated or multiple structural congenital anomalies. Outcomes: To provide better counselling for women and families who are dealing with the diagnosis of a fetal structural anomaly.(More)