Clémence Meunier

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There is growing concern over confounding artifacts associated with β-cell-specific Cre-recombinase transgenic models, raising questions about their general usefulness in research. The inducible β-cell-specific transgenic (MIP-CreERT(1Lphi)) mouse was designed to circumvent many of these issues, and we investigated whether this tool effectively addressed(More)
Adult social behaviour can be persistently modified by early-life social experience. In rodents, such effects are induced by tactile maternal stimulation resulting in neuroendocrine modifications of the hypothalamic-pituitary-adrenal axis involved in stress responsiveness. Whether similar long-term alterations can occur in the(More)
HIV-1 infection causes depletion and/or dysfunction of distinct CD4(+) T cell subsets and may affect these differently. Using the CD4C/HIV-1(Nef) transgenic (Tg) mice as a model, we report that HIV-1 Nef causes depletion of total CD4(+) T cells, but preserves and relatively enriches CD4(+) regulatory T cells (Treg). We found that Nef-mediated CD4(+) Treg(More)
There is growing concern over confounding artifacts associated with b-cell–specific Cre-recombinase transgenic models, raising questions about their general usefulness in research. The inducible b-cell–specific transgenic (MIP-CreERT) mouse was designed to circumvent many of these issues, and we investigated whether this tool effectively addressed concerns(More)
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