Ciro Caruso

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Corneal accumulation of riboflavin-5'-phosphate (riboflavin) is an essential step in the so called corneal cross-linking (CXL), an elective therapy for the treatment of progressive keratoconus, corneal ectasia and irregular astigmatism. CXL is usually performed after surgical debridement of corneal epithelium, since it impedes the stromal penetration of(More)
PURPOSE To report the clinical outcomes with 24-month follow-up of transepithelial cross-linking using a combination of a D-alpha-tocopheryl polyethylene-glycol 1000 succinate (vitamin E-TPGS)-enhanced riboflavin solution and abbreviated low fluence UV-A treatment. METHODS In a nonrandomized clinical trial, 25 corneas of 19 patients with topographically(More)
Purpose: a time-dependent mathematical model of UV-A absorption and of riboflavin consumption During cross-linking treatments, the intensity of the UV-A shaft that exits from the rear side of a treated cornea generally varies with time. Therefore, a time-dependent mathematical model is necessary to describe cross-linking treatments. Wherein:  R A (z,t):(More)
INTRODUCTION Abdominal angina occurs in patients affected by mesenteric artery obstruction, causing postprandial episodes of visceral pain. The conventional treatment consists of vessels revascularization, but sometimes this is not applicable. CASE REPORT The authors report a case of a patient with severe abdominal angina caused by mesenteric ischemia,(More)
PURPOSE To determine the cross-linking effect of a riboflavin ultraviolet-A (UV-A) corneal cross-linking treatment that is both shorter and has lower energy than the Dresden protocol. METHODS In a first experiment, 12 human corneas were presoaked with riboflavin and then irradiated with UV-A at 3 mW/cm after clearing the surface of riboflavin, with no(More)
PURPOSE To improve the safety, reproducibility, and depth of effect of corneal cross-linking with the ultraviolet A (UV-A) exposure time and fluence customized according to the corneal thickness. METHODS Twelve human corneas were used for the experimental protocol. They were soaked using a transepithelial (EPI-ON) technique using riboflavin with the(More)
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