Ciro Bancone

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OBJECTIVE This study aimed to describe the features and identify the predictors of ascending aorta dilatation in patients with congenital bicuspid aortic valve (BAV). METHODS In 280 adult patients with isolated BAV undergoing echocardiography, multivariate logistic regression models, including clinical and echocardiographic variables, were developed to(More)
An understanding of aortic root biomechanics is pivotal for the optimisation of surgical procedures aimed at restoring normal root function in pathological subjects. For this purpose, computational models can provide important information, as long as they realistically capture the main anatomical and functional features of the aortic root. Here we present a(More)
OBJECTIVE Bicuspid aortic valve disease is heterogeneous with respect to valve morphology and aortopathy risk. This study searched for early imaging predictors of aortopathy in patients with a bicuspid aortic valve with right-left coronary cusp fusion, the most common morphotype. METHODS Time-resolved magnetic resonance imaging was performed in 36(More)
OBJECTIVE Congenital bicuspid aortic valves frequently cause aortic stenosis or regurgitation. Improved understanding of valve and root biomechanics is needed to achieve advancements in surgical repair techniques. By using imaging-derived data, finite element models were developed to quantify aortic valve and root biomechanical alterations associated with(More)
OBJECTIVE The present study examined temporal and spatial patterns of extracellular matrix and smooth muscle cell changes in the ascending aorta with bicuspid and tricuspid aortic valve stenosis. METHODS Wall specimens were retrieved from both the greater and the lesser curvature ("convexity" and "concavity") of 14 nonaneurysmal and 12 aneurysmal aortas(More)
MicroRNAs are able to modulate gene expression in a range of diseases. We focused on microRNAs as potential contributors to the pathogenesis of ascending aorta (AA) dilatation in patients with stenotic tricuspid (TAV) or bicuspid aortic valve (BAV). Aortic specimens were collected from the ‘concavity’ and the ‘convexity’ of mildly dilated AAs and of normal(More)
BACKGROUND AND AIM OF THE STUDY The RIFLE classification, which defines three grades of increasing severity of acute kidney injury--risk (RIFLE R), injury (RIFLE I) and failure (RIFLE F), and two outcome classes (L, loss) and E (end-stage kidney disease)--represents a valuable method for evaluating acute renal failure. Risk factors for acute kidney injury(More)
  • Alessandro Della Corte, Ciro Bancone
  • European journal of cardio-thoracic surgery…
  • 2012
We read with interest the paper by Jackson et al. [1] reporting the absence of association between valve morphology and ascending aorta configuration in 300 bicuspid aortic valve (BAV) patients referred for surgery. Although previous studies had already addressed the phenotypic heterogeneity of BAV aortopathy [2, 3], the authors were the first to use(More)
OBJECTIVES Different methods to classify the anatomical configurations of the aorta with bicuspid aortic valve (BAV) have been proposed. We aimed to test them in terms of descriptive power (i.e. capability to identify different clusters of patients with unique associations of anatomo-clinical features) and possible prognostic significance. METHODS A(More)
Adult human heart hosts a population of cardiac primitive CD117-positive cells (CPCs), which are responsible for physiological tissue homeostasis and regeneration. While the bona fide stem cells express telomerase, their progenies are no longer able to preserve telomeric DNA; hence the balance between their proliferation and differentiation has to be(More)