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Multiple sclerosis is a disease of unknown aetiology. Despite several advances in therapy in recent years, some problems such as the prognostic criteria are imperfectly understood. Several experimental trials of therapy in multiple sclerosis are in course in order to discover a successful treatment. Most of these research studies use a clinical rating scale(More)
This is a study on the longitudinal evaluation of cognitive functions in multiple sclerosis (MS) patients and their quality of life (QoL). The study follow-up lasted for 3 years and the evaluation was performed every 9 months for four times altogether. We present data on the first and second session, when we evaluated the frontal component of cognitive(More)
The aim of the study was to estimate the rate of conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) and to investigate variables predicting conversion in a cohort of patients presenting with symptoms suggestive of MS. Patients with a first symptom suggestive of MS in the preceding 6 months and exclusion of other diseases were(More)
Endogenous opioid peptides tonically inhibit LH by acting on hypothalamic mechanisms which regulate LHRH secretion. Opiates increase hypothalamic serotonin turnover but the involvement of the serotoninergic system in the opioid mechanisms regulating LH secretion in man is not clear at present. This study was designed to evaluate whether the tonic inhibitory(More)
The expanded disability status scale (EDSS) has been the most widely used measure of disability in multiple sclerosis (MS) clinical trials. Although EDSS has the advantage of familiarity with respect to recent proposals, and remains the de facto standard, it is difficult to use consistently between evaluators. Automatic EDSS (AEDSS) is an expert system(More)
Urinary disorders are uncommon in the initial phases of multiple sclerosis, but increase in frequency as the disease progresses, with a negative impact on quality of life. The goal of this study was to propose a protocol for the diagnosis and treatment of urinary disorders in multiple sclerosis, based on data from the scientific literature and the(More)
OBJECTIVE To study sleep-wake and body core temperature (BCT) circadian rhythms in patients with multiple sclerosis (MS)-associated with chronic fatigue. METHODS Six relapsing-remitting MS patients with chronic fatigue underwent 48 consecutive hours polysomnography (PSG) with BCT measurement, followed by a Multiple Sleep Latency Test (MSLT). All patients(More)
Endogenous opioid peptides exert a tonic inhibition on gonadotropin secretion at the hypothalamic level, but the mechanisms by which they act are still unknown. Previous experimental studies suggest that the endogenous opioid peptides change dopaminergic and serotoninergic tones at the hypothalamic level. We have investigated whether the stimulatory effect(More)
The aim of this study was to examine the role of the central dopaminergic system in the mechanisms by which opioid peptides exert their influence on luteinizing hormone (LH) secretion in man. The effects of sulpiride and naloxone on the changes in LH secretion induced by a metenkephalin analog (D-Ala2-MePhe4-Met-(o)-ol-Enkephalin, FK 33824, Sandoz, Basel,(More)
The Expanded Disability Status Scale (EDSS) has been the most widely used measure of disability in multiple sclerosis clinical trials. Although EDSS has the advantage of familiarity with respect to recent proposals, yet is difficult to use consistently between evaluators. AEDSS (Automatic EDSS) is a computerized system designed to overcome this problem. It(More)