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The semantic web envisions a World Wide Web in which data is described with rich semantics and applications can pose complex queries. Ontologies, a cornerstone of the semantic web, have gained wide popularity as a model of information in a given domain that can be used for many purposes, including enterprise integration, database design, information(More)
A graph is a fundamental and general data structure underlying all data applications. Many applications today call for the management and query capabilities directly on graphs. Real time graph streams, as seen in road networks, social and communication networks , and web requests, are such applications. Event pattern matching requires the awareness of graph(More)
MK-0869 (aprepitant), a potent substance P antagonist, is the active ingredient of EMEND which has recently been approved by the FDA for the prevention of chemotherapy-induced nausea and vomiting. Early clinical tablet formulations of MK-0869 showed significant food effects on absorption, suggesting that formulation could have a significant role in(More)
Fanconi anemia (FA) is an inherited cancer susceptibility syndrome caused by mutations in a DNA repair pathway including at least 6 genes (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG). The clinical course of the disease is dominated by progressive, life-threatening bone marrow failure and high incidence of acute myelogenous leukemia and solid tumors.(More)
Due to the inherent immune evasion properties of the HIV envelope, broadly neutralizing HIV-specific antibodies capable of suppressing HIV infection are rarely produced by infected individuals. We examined the feasibility of utilizing genetic engineering to circumvent the restricted capacity of individuals to endogenously produce broadly neutralizing(More)
We present a valid-time extension of SQL and investigate its efficient implementation on an Object-Relational database system. We propose an approach where temporal queries are expressed using a point-based time model, which only requires minimal extensions to SQL:1999. Our prototype system called TENORS (for Temporal ENhanced Object-Relational System) maps(More)
Online dating sites have become popular platforms for people to look for potential romantic partners. It is important to understand users' dating preferences in order to make better recommendations on potential dates. The message sending and replying actions of a user are strong indicators for what he/she is looking for in a potential date and reflect the(More)