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TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia.

• Olivier Kosmider, Véronique Gelsi-Boyer, +16 authors Éric Solary
• Haematologica
• 2009

BACKGROUND Acquired somatic deletions and loss-of-function mutations in one or several codons of the TET2 (Ten-Eleven Translocation-2) gene were recently identified in hematopoietic cells from… (More)

Use of Human Cancer Cell Lines Mitochondria to Explore the Mechanisms of BH3 Peptides and ABT-737-Induced Mitochondrial Membrane Permeabilization

• Nelly Buron, M Porceddu, +7 authors Annie Borgne-Sanchez
• PloS one
• 2010

Current limitations of chemotherapy include toxicity on healthy tissues and multidrug resistance of malignant cells. A number of recent anti-cancer strategies aim at targeting the mitochondrial… (More)

Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity.

• Olivier Burgy, Guillaume Wettstein, +10 authors Philippe Bonniaud
• Science translational medicine
• 2016

Bleomycin (BLM) is a potent anticancer drug used to treat different malignancies, mainly lymphomas, germ cell tumors, and melanomas. Unfortunately, BLM has major, dose-dependent, pulmonary toxicity… (More)

Towards the elaboration of new gold-based optical theranostics.

• Pierre-Emmanuel Doulain, Richard A. Decréau, +8 authors Ewen Bodio
• Dalton transactions
• 2015

Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical… (More)

H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway

• Marion Cortier, Rahamata Boina-Ali, +4 authors Ali Bettaieb
• Oncotarget
• 2015

High doses of the organic nitrate glyceryl trinitrate (GTN), a nitric oxide (NO) donor, are known to trigger apoptosis in human cancer cells. Here, we show that such a cytotoxic effect can be… (More)

MYELOID NEOPLASIA Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia

• Nathalie M. Droin, Arnaud Jacquel, +14 authors Éric Solary
• 2009

1Inserm UMR866, Dijon; 2Faculty of Medicine, University of Burgundy, Dijon; 3Centre Hospitalier Universitaire (CHU) Le Bocage, CLIPP Platform, Dijon; 4Centre Georges François Leclerc, CLIPP Platform,… (More)

Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia.

• Nathalie M. Droin, Arnaud Jacquel, +14 authors Éric Solary
• Blood
• 2010

Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder that occurs in elderly patients. One of the main diagnostic criteria is the accumulation of heterogeneous monocytes in the… (More)

TLR4/IFNγ pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models.

• Myriam Lamrani, Néjia Sassi, +12 authors Jean-Françcois Jeannin
• Oncoimmunology
• 2016

Toll-like receptor (TLR) 4 agonists have emerged as a new group of molecules used for cancer therapy. They have been exploited to enhance the immunogenicity of current chemotherapeutic regimens.… (More)

Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages.

• Arnaud Jacquel, Naïma Benikhlef, +9 authors Éric Solary
• Blood
• 2009

The differentiation of human peripheral blood monocytes into resident macrophages is driven by colony-stimulating factor-1 (CSF-1), which upon interaction with CSF-1 receptor (CSF-1R) induces within… (More)

Senescence of tumor cells induced by oxaliplatin increases the efficiency of a lipid A immunotherapy via the recruitment of neutrophils

• Cédric Seignez, Amandine Martin, +5 authors C Nliranjan Paul
• Oncotarget
• 2014

Management of advanced colorectal cancer is challenging due to the lack of efficient therapy. The lipid A, OM-174 exhibited antitumor activity in colorectal cancer. We explored the anticancer… (More)

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