Cigil Sebastian

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Alginic acid was evaluated as a potential vehicle in ophthalmic solutions for prolonging the therapeutic effect of carteolol. This anionic vehicle was expected to slow down drug elimination by the lacrimal flow, both by undergoing in-situ gel formation and by interacting with the mucus. In vitro studies indicated that carteolol is released slowly from(More)
Young fish (Oreochromis mossambicus) were exposed to microgravity (micro g) for 9 to 10 days during space missions STS-55 and STS-84, or to hypergravity (hg) for 9 days. Young animals (stages 11-12), which had not yet developed the roll-induced static vestibuloocular reflex (rVOR) at micro g- and hg-onset, and older ones (stages 14-16), which had already(More)
The effects of altered gravitational forces (AGF) on the development of the static vestibulo-ocular reflex (VOR) were investigated in Xenopus laevis tadpoles exposed to hypergravity (1.4g; 3g) or microgravity conditions (German spacelab mission D-2) for 9-10 days. The effects of light conditions during development were also tested by exposing tadpoles to(More)
In tadpoles of Xenopus laevis, the effects of microgravity on the development of the roll-induced vestibuloocular reflex (rVOR) was investigated. Special attention was focused on sensitive periods and the minimum duration of microgravity exposure by which the development of the rVOR is affected. The peak-to-peak excursion (rVOR amplitude) of the rVOR(More)
The effects of altered gravitational conditions (AGC) on the development of the static vestibulo-ocular reflex (VOR) and readaptation to 1g were investigated in the amphibian Xenopus laevis. Tadpoles were exposed to microgravity during the German Space Mission D-2 for 10 days, using the STATEX closed survival system, or to 3g for 9 days during earth-bound(More)
In Xenopus laevis tadpoles, we studied the static vestibuloocular reflex (rVOR) in relation to modifications of the gravitational environment to find basic mechanisms of how altered gravitational forces (AGF) affect this reflex. Animals were exposed to microgravity during space flight or hypergravity (3g) for 4 to 12 days. Basic observations were that(More)
Young fish (Oreochromis mossambicus) were exposed to microgravity (micro g) for 9 to 10 days, or to hypergravity (hg) for 9 days. For several weeks after termination of micro g and hg, the roll-induced static vestibuloocular reflex (rVOR) was recorded. In stage 11/12-fish, the rVOR amplitude (angle between the maximal up and down movement of an eye during a(More)
— Lean manufacturing is a systematic approach to identifying and eliminating wastes (non-value added activities) through continuous improvement by conveying the product at the pull of the customer in pursuit of production. In a more basic term, more value with less work. Lean manufacturing appears to hold considerable promise for addressing a range of(More)
In tadpoles of Xenopus laevis, the effects of an exposure to hypergravity on the development of the roll-induced static vestibuloocular reflex (rVOR) were investigated. Special attention was given to the onset of the 9 or 12 days lasting 3 g period during early life. Recordings of rVOR characteristics for complete 360 degrees rolls of the tadpoles started(More)