Ciaran M J Healy

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PURPOSE Sentinel node biopsy (SNB) is a surgical technique for detecting micrometastatic disease in the regional draining nodes. 2-fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) scanning is an imaging technique that can detect clinically undetectable metastases. This prospective study was undertaken to compare the sensitivity of(More)
Host-induced antibodies and their contributions to cancer inflammation are largely unexplored. IgG4 subclass antibodies are present in IL-10-driven Th2 immune responses in some inflammatory conditions. Since Th2-biased inflammation is a hallmark of tumor microenvironments, we investigated the presence and functional implications of IgG4 in malignant(More)
BACKGROUND S100 protein is an acidic calcium binding protein that is expressed by melanoma cells. Elevated serum values of S100 have been described in metastatic disease and it has been suggested that it may be used as an adjunct to staging and monitoring of treatment. Micrometastatic disease in the sentinel lymph node can be demonstrated by sentinel node(More)
BACKGROUND Full-thickness defects to the plantar surface of the foot present a challenge to the reconstructive surgeon. Skin grafts and a variety of flap procedures have been described to resurface this site, but not all achieve a return to normal foot function. For the plantar surface of the heel, the previously described medial plantar flap can produce(More)
The use of fibrin sealant to secure the mesh after a hernia repair, and to reduce seroma formation after abdominoplasty, is well recognised. However, delivery of the fibrin sealant post-abdominoplasty has proved technically difficult due to the competing demands of: (1) applying instant pressure to the fibrin sealant-containing cavity and (2) accurate(More)
Positron emission tomography (PET) is increasingly used for the staging and management of melanoma. The aim of this study was to evaluate the role of PET or PET/ computed tomography (CT) as a routine procedure in patients with positive sentinel node biopsy (SNB). Thirty patients with melanoma of Breslow thickness greater than 1 mm who had PET or PET/CT(More)
OBJECTIVE The management of metastatic melanoma remains challenging with only modest response rates to chemotherapy but the need to identify the best re-staging techniques remains paramount. This study evaluates our early experience in the use of FDG PET-CT in the assessment of early response to chemotherapy in metastatic melanoma. METHODS FDG PET-CT was(More)