Cian P McCarthy

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Since the introduction of closed chest synchronized DC shock treatment for atrial fibrillation by Lown in 1962 (Lown, Amarasingham, and Newman, 1962a; Lown et al., 1962b) many thousands of patients have undergone this treatment. Complications have occurred on occasion. Arrhythmias, some fatal, have been reported by Ross (1964), Morris et al. (1964), Killip(More)
A unique case of dissecting aneurysm of the aorta is presented. The dissection spread via a ductus arteriosus to the pulmonary artery andformed a re-entry window at the junction of the main and left pulmonary arteries. Cardiac catheterization and angiocardiography confirmed the presence and approximate site of thefistula. Surgery under cardiopulmonary(More)
Morphine, oxygen, and nitrates are time-honored therapies for the initial management of acute coronary syndrome (ACS). The traditional goal of these agents in ACS has been to (1) relieve symptoms, (2) prevent infarction or limit its size, and (3) improve outcomes, both acutely and during follow-up. Despite their ongoing use in routine ACS care, nitrates,(More)
Using chemical inhibitors to reduce soil nitrification decreases emissions of environmental damaging nitrate and nitrous oxide and improves nitrogen use efficiency in agricultural systems. The efficacy of nitrification inhibitors such as dicyandiamide (DCD) is limited in soil due to biodegradation. This study investigated if the persistence of DCD could be(More)
With potent analgesic properties, perceived hemodynamic benefits and limited alternatives, morphine is the analgesic mainstay for patients with nitrate resistant chest pain due to acute Myocardial Infarction (MI). However, observational data suggest that morphine administration during MI may have negative consequences. While vomiting, hypotension and(More)
With evidence for efficacy in such diverse clinical settings such as stable coronary artery disease, reperfusion injury, and contrast-induced nephropathy, trimetazidine (TMZ) is novel among cardiovascular agents. In spite of this and almost half a century of clinical experience with the drug, it remains licensed only as an adjunct in the management of(More)
Asymptomatic but hemodynamically severe aortic stenosis often poses a dilemma: should the aortic valve be replaced, or is watchful waiting acceptable? Patients with this condition are a diverse group with varying prognoses. Here, we review the guidelines for valve replacement in this situation and highlight the variables useful in establishing which(More)
Biomarkers are important prognostic tools in various cardiovascular conditions, including coronary artery disease and heart failure. Although their utility in cardiac electrophysiology (EP) is less established, biomarkers may guide EP clinical practice by identifying patients at risk for developing arrhythmias and their complications, in addition to(More)