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Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine
The results not only suggest the importance of mMate1 in the efflux of organic cations into the urine and bile in mice but also the important of canalicular efflux mediated by MATE proteins for the therapeutic efficacy of metformin.
Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP
The effect of curcumin, the principalCurcuminoid of turmeric, on oral bioavailability of microdoses and therapeutic doses of sulphasalazine in humans is examined.
Identification of the major metabolites of resveratrol in rat urine by HPLC-MS/MS.
To identify the major metabolites of resveratrol in rat, rat urine samples were pretreated by using solid-phase extraction technique (SPE) with polyamide cartridges. And a LC-MS/MS method with
Systematic identification and quantification of tetracyclic monoterpenoid oxindole alkaloids in Uncaria rhynchophylla and their fragmentations in Q-TOF-MS spectra.
The chemical constituents, including alkaloids, flavonoids, and quinic acids, in UR have been systematically identified and quantified by a developed method of high-performance liquid chromatography coupled with diode-array detection and quadrupole time-of-flight mass spectrometry (Q-TOF-MS).
Evaluation of Breast Cancer Resistance Protein Function in Hepatobiliary and Renal Excretion Using PET with 11C-SC-62807
It is demonstrated that Bcrp plays a significant role in the efflux of 11C-SC-62807 in mouse liver and kidney and the feasibility of PET using 11C of the organic anion-transporting polypeptides OATP1B1 and OATF3 in vitro is demonstrated.
Degradation kinetics study of cabozantinib by a novel stability-indicating LC method and identification of its major degradation products by LC/TOF-MS and LC-MS/MS.
A V-shaped pH-rate profile over the pH range 2-10 was observed with maximum stability at pH 6.5 and the effect of temperature on the rate of CBZ degradation was characterized using the Arrhenius equation.
Comparative analysis of three Callicarpa herbs using high performance liquid chromatography with diode array detector and electrospray ionization-trap mass spectrometry method.
High-performance liquid chromatography coupled with diode array detector and electrospray ionization trap mass spectrometry (HPLC-DAD-ESI-Trap MS) technique was used for qualitative and quantitative analyses of the three Callicarpa herbs.
Large Size Microneedle Patch to Deliver Lidocaine through Skin
The large size microneedle array patch showed fast onset and sustained delivery of LD through skin, potentially useful to increase the application scope of topical LD for pain management.
Characterization and simultaneous quantification of multiple constituents in Aurantii Fructus Immaturus extracts by HPLC-DAD-ESI-MS/MS
Abstract Aim To develop a sensitive and accurate analytical method for the profiling, identification and simultaneous quantification of the chemical constituents in Aurantii Fructus Immaturus