Chunying Zhao

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The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of silvestrol and related compounds. For example, eIF4A promotes T-cell acute lymphoblastic leukaemia development in vivo and(More)
The RAS/RAF/MEK/ERK (MAPK) signaling cascade plays a crucial regulatory role in normal cell functions such as proliferation, survival, differentiation, motility and angiogenesis. 1 This pathway is among the most frequently activated in cancer. 2 Sustained MAPK activation is important in a number of hematologic malignancies: in acute myeloid leukemia (AML),(More)
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