Chunying Zhao

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The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of silvestrol and related compounds. For example, eIF4A promotes T-cell acute lymphoblastic leukaemia development in vivo and(More)
This paper presents a graph transformation based approach to design pattern evolution. An evolution of a design pattern includes modifications of pattern elements, such as classes, attributes, operations and relationships between classes. Compared with other techniques, graphical notation, as a natural and intuitive way in software modeling, is suitable to(More)
Recovering software behaviors from execution traces is useful in program comprehension and maintenance. Multiple executions upon different test inputs can help to locate program behaviors related to a particular use case, i.e. a specific functionality. An abstraction and visualization environment <i>Abstracer</i> was developed, and experiments have been(More)
—Discovering program behaviors and functionalities can ease program comprehension and verification. Existing program analysis approaches have used text mining algorithms to infer behavior patterns or formal models from program execution. When one tries to identify the hierarchical composition of a program behavior at different abstraction levels, textual(More)
Frequent patterns in program executions represent recurring sequences of events. These patterns can be used to reveal the hidden structures of a program, and ease the comprehension of legacy systems. Existing grammar-induction approaches generally use sequential algorithms to infer formal models from program executions, in which program executions are(More)
Infantile neuroaxonal dystrophy (INAD) is a progressive, autosomal recessive neurodegenerative disease characterized by axonal dystrophy, abnormal iron deposition and cerebellar atrophy. This disease was recently mapped to PLA2G6, which encodes group VI Ca(2+)-independent phospholipase A(2) (iPLA(2) or iPLA(2)β). Here we show that genetic ablation of PLA2G6(More)