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The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of silvestrol and related compounds. For example, eIF4A promotes T-cell acute lymphoblastic leukaemia development in vivo and(More)
Infantile neuroaxonal dystrophy (INAD) is a progressive, autosomal recessive neurodegenerative disease characterized by axonal dystrophy, abnormal iron deposition and cerebellar atrophy. This disease was recently mapped to PLA2G6, which encodes group VI Ca(2+)-independent phospholipase A(2) (iPLA(2) or iPLA(2)β). Here we show that genetic ablation of PLA2G6(More)
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: Abstract In recent years, design patterns gain more interest in software engineering(More)
Mitochondria-mediated production of reactive oxygen species (ROS) plays a key role in apoptosis. Mitochondrial phospholipid cardiolipin molecules are likely the main target of ROS because they are particularly rich in polyunsaturated fatty acids. They are also located in the inner mitochondrial membrane near the ROS-producing sites. Under physiological(More)
This paper presents a graph transformation based approach to design pattern evolution. An evolution of a design pattern includes modifications of pattern elements, such as classes, attributes, operations and relationships between classes. Compared with other techniques, graphical notation, as a natural and intuitive way in software modeling, is suitable to(More)
—Discovering program behaviors and functionalities can ease program comprehension and verification. Existing program analysis approaches have used text mining algorithms to infer behavior patterns or formal models from program execution. When one tries to identify the hierarchical composition of a program behavior at different abstraction levels, textual(More)
Recovering software behaviors from execution traces is useful in program comprehension and maintenance. Multiple executions upon different test inputs can help to locate program behaviors related to a particular use case, i.e. a specific functionality. An abstraction and visualization environment <i>Abstracer</i> was developed, and experiments have been(More)
The authors conducted a case-control study of Parkinson's disease patients with and without visual hallucinations to investigate associations of the polymorphisms of the dopamine receptors D2 32806 C>T (Taq1A), D3 Ser9Gly and Msp1, D5 978T>C and dopamine transporter 3'-UTR 40 bp VNTR with visual hallucinations in Parkinson's disease. No significant(More)