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Activation of NF-κB contributes to cardiac hypertrophy and the interleukin-1 receptor (IL-1R)-mediated MyD88-dependent signaling pathway predominately activates NF-κB. Recent studies have shown that the TIR/BB-Loop mimetic (AS-1) disrupted the interaction of MyD88 with the IL-1R, resulting in blunting of NF-κB activation. We have examined the effects of(More)
OBJECTIVE Plasma fibrinogen has been defined as a risk factor of cardiovascular disease and may play a role in the development of cardiac hypertrophy. We have previously demonstrated that the Toll-like receptor 4 (TLR4)-mediated myeloid differentiation primary response protein 88 (MyD88)-dependent nuclear factor-kappaB (NF-kappaB) pathway is involved in(More)
Real world Web mining applications usually have different requirements, such as massive data processing, low system latency, and high scalability. In order to meet these different requirements, we proposed a distributed text mining system with a layered architecture that divides the system functions into three layers, namely, the crawling and storage layer,(More)
Community detection is a long-standing yet very difficult task in social network analysis. It becomes more challenging as many online social networking sites are evolving into super-large scales. Numerous methods have been proposed for community detection from massive networks, but how to reconcile the partitioning efficiency and the community quality(More)
Probabilistic frequent pattern mining over uncertain data has received a great deal of attention recently due to the wide applications of uncertain data. Similar to its counterpart in deterministic databases, however, prob-abilistic frequent pattern mining suffers from the same problem of generating an exponential number of result patterns. The large number(More)
Mining probabilistic frequent patterns from uncertain data has received a great deal of attention in recent years due to the wide applications. However, probabilistic frequent pattern mining suffers from the problem that an exponential number of result patterns are generated, which seriously hinders further evaluation and analysis. In this paper, we focus(More)
Current predictors for estrogen receptor-positive (ER-positive) breast cancer patients receiving tamoxifen are often invalid in inter-laboratory validation. We aim to develop a robust predictor based on the relative ordering of expression measurement (ROE) in gene pairs. Using a large integrated dataset of 420 normal controls and 1,129 ER-positive breast(More)