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Clinical and animal studies demonstrated that orally administered berberine had a distinct lipid-lowering effect. However, pharmacokinetic studies showed that berberine was poorly absorbed into the… Continue Reading
BACKGROUND Metabolomics allows the high-throughput analysis of low molecular mass compounds in biofluids, which can reflect the metabolic response of the body to heroin exposure and potentially… Continue Reading
Kukoamines are a series of bioactive phytochemicals conjugated by a polyamine backbone and phenolic moieties. Understanding the structural diversity of kukoamine metabolites in plants is meaningful… Continue Reading
Abstract Fusarium wilt of pepper outbreaks in the region where pepper crop has been grown for many years and it has already become a major phytopathogen all over the world. The goal of this study is… Continue Reading
BackgroundCellulosic biofuels are sustainable compared to fossil fuels. However, inhibitors, such as acetic acid generated during lignocellulose pretreatment and hydrolysis, would significantly… Continue Reading
For orally administered drugs, the metabolism of a drug by the gut flora plays an important role in the bioavailability, activation and disposition of the drug in vivo. However, no in vitro system is… Continue Reading
Correction for 'A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine' by Shenghua Gu et al., Mol. BioSyst., 2015, DOI: .
Cell culture and stable transfection. The B16 cells were cultured in RPMI with 10% (v/v) fetal bovine serum (FBS), 50 U/mL penicillin, 50 μg/mL streptomycin, 2 mM L-glutamine. The HCT116 cells were… Continue Reading
H om ol og y to K no w n A e. a eg yp ti G en es 75 1.1657 AAEL012117 545 1.93 AAEL003613 1476 1.9 AAEL000509 3324 1.1411 AAEL015034 3738 1.195 AAEL006222 4203 1.4383 AAEL017530 4627 1.82 1q43… Continue Reading