Learn More
PURPOSE Trastuzumab emtansine (T-DM1), an antibody-drug conjugate composed of the cytotoxic agent DM1 conjugated to trastuzumab via a stable thioether linker, has shown clinical activity in single-arm studies enrolling patients with human epidermal growth factor receptor 2 (HER2) -positive metastatic breast cancer (MBC) whose disease had progressed on(More)
Impossible differential cryptanalysis is a method recovering secret key by getting rid of the keys that satisfy impossible differential relations. This cryptanalysis has been used to attack AES and many good results were gotten. For the new block cipher ARIA is similar to AES in structure, it is necessary to research its security against impossible(More)
Activation of mu-opioid receptors (MORs) transfected into human embryonic kidney 293 cells, caused a multiphasic increase in cytosolic free Ca(2+) levels (Ca(2+)i). The first Ca(2+)i maximum (peak 1) between 5 and 7 s depended on the presence of extracellular Ca(2+) (Ca(2+)e). The second phase peaking at approximately 15 s (peak 2) was independent of(More)
This phase I study evaluated selective JAK2 inhibitor XL019 in 30 patients with myelofibrosis. The initial dose cohorts were 100, 200, and 300 mg orally on days 1-21 of a 28-day cycle. Central and/or peripheral neurotoxicity developed in all patients. Subsequently, patients were treated on lower doses; neurotoxicity was again observed, leading to study(More)
Feature extraction is a key point of pattern recognition. Wavelet features are attractive for vehicle detection because they form a compact representation, encode edges, capture information from multi-resolution, and can be computed efficiently. This paper focuses on the improvement of wavelet features. The wavelet features directly based on signed(More)
Workflow Management System is used for supporting many day-to-day workflows in large organizations. But heterogeneous and distributed computing systems make security management of WFMS decentralized, thus its security must be noticed. In this paper, we propose a role-based secure workflow model which realizes the principle of separation of duties (SoD), the(More)
A monocular vision based location algorithm is presented to detect and track rear vehicles for lane change assist. The algorithm uses the shadow underneath the vehicle to extract regions of interest (ROI), and then locates vehicles with the combination of symmetry, contour and the shadow underneath a vehicle. Three symmetry criteri-ons are proposed to(More)
The omega (ome) gene product is a modifier of larval cuticle protein 5 and its alleles (and duplicates) in the third instar of Drosophila melanogaster. Using deletion mapping the locus mapped to 70F-71A on the left arm of chromosome 3. A homozygote null mutant (ome 1) shows a pleiotropic phenotype that affected the size, developmental time of the flies, and(More)
PURPOSE In rods saturated by light, the G protein transducin undergoes translocation from the outer segment compartment, which results in the uncoupling of transducin from its innate receptor, rhodopsin. We measured the kinetics of recovery from this adaptive cellular response, while also investigating the role of phosducin, a phosphoprotein binding(More)