Chunyan Jiang

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Mammalian pre-implantation development is a complex process involving dramatic changes in the transcriptional architecture. We report here a comprehensive analysis of transcriptome dynamics from oocyte to morula in both human and mouse embryos, using single-cell RNA sequencing. Based on single-nucleotide variants in human blastomere messenger RNAs and(More)
Myofibroblasts produce the fibrous scar in hepatic fibrosis. In the carbon tetrachloride (CCl(4)) model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become myofibroblasts. When the underlying etiological agent is removed, clinical and experimental fibrosis undergoes a remarkable regression with complete disappearance of these(More)
BACKGROUND locking intramedullary nails and locking plates specially designed for proximal humeral fractures are widely used. The purpose of our study was to compare the outcomes between these two types of implants in patients with a two-part surgical neck fracture. The advantages and shortcomings of each method were analyzed. METHODS a prospective(More)
Hepatic myofibroblasts are activated in response to chronic liver injury of any etiology to produce a fibrous scar. Despite extensive studies, the origin of myofibroblasts in different types of fibrotic liver diseases is unresolved. To identify distinct populations of myofibroblasts and quantify their contribution to hepatic fibrosis of two different(More)
BACKGROUND Engaging Hill-Sachs lesions are known to be a risk factor for recurrence dislocation after arthroscopic repair in patients with anterior shoulder instability. For a large engaging Hill-Sachs lesion, arthroscopic remplissage is a solution. HYPOTHESIS Arthroscopic Bankart repair combined with the Hill-Sachs remplissage technique can achieve good(More)
Salinomycin is widely used in animal husbandry as a food additive due to its antibacterial and anticoccidial activities. However, its biosynthesis had only been studied by feeding experiments with isotope-labeled precursors. A strategy with degenerate primers based on the polyether-specific epoxidase sequences was successfully developed to clone the(More)
BACKGROUND Very few studies have compared open Latarjet versus arthroscopic Latarjet procedures. PURPOSE To compare the clinical and computed tomographic outcomes between open and arthroscopic Latarjet procedures. STUDY DESIGN Cohort study; Level of evidence, 3. METHODS A prospective, comparative study was performed. The open Latarjet group included(More)
BACKGROUND We report an alternative to the modified Weaver-Dunn technique that can achieve stable coracoclavicular reconstruction while avoiding sacrifice of the coracoacromial arch. The purpose of this study was to retrospectively analyze the functional outcomes and radiographic features of patients treated with coracoclavicular ligament reconstruction(More)
Nowadays, the inside situation could be obtained by medical machines, such as computed tomography (CT), magnetic resonance imaging (MRI) scanner, etc. These noninvasive diagnosis means increase the precision of the diagnoses, at the same time decrease the pain of the patients. Brain tumor diagnoses benefit from these devises very much. In the brain MR(More)
BACKGROUND This study proposes a simple and reliable classification system to evaluate the severity of the bone resorption of the transferred coracoid bone block after the Latarjet procedure. The incidence and severity of the graft resorption was also investigated. METHODS Between January 2009 and January 2012, 63 patients underwent an open Latarjet(More)