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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
TLDR
The results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer. Expand
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
TLDR
Analysis of TCC by whole-genome and whole-exome sequencing provides evidence that genetic alterations affecting the SCCS process may be involved in bladder tumorigenesis and identifies a new therapeutic possibility for bladder cancer. Expand
Transurethral enucleation and resection of prostate in patients with benign prostatic hyperplasia by plasma kinetics.
TLDR
Transurethral enucleation and resection of the prostate induced significant, pronounced, immediate and lasting improvement in the International Prostate Symptom Score, quality of life, maximum urinary flow and post-void residual urine volume. Expand
Effect of Laparoscopic vs Open Distal Gastrectomy on 3-Year Disease-Free Survival in Patients With Locally Advanced Gastric Cancer: The CLASS-01 Randomized Clinical Trial.
TLDR
Among patients with a preoperative clinical stage indicating locally advanced gastric cancer, laparoscopic distal Gastrectomy compared with open distal gastrectomy, did not result in inferior disease-free survival at 3 years. Expand
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease.
TLDR
The results indicate that PD stresses activate AMPK and inactivate Akt, causing neuronal cell death via inhibiting mTOR-mediated S6K1 and 4E-BP1 pathways, and suggest that proper co-manipulation of AMPK/Akt/mTOR signaling may be a potential strategy for prevention and treatment of PD. Expand
Prostate cancer in Asia: A collaborative report
TLDR
This collaborative report summarized the latest epidemiology information, risk factors, and racial differences in PCa diagnosis, current status and new trends in surgery management and novel agents for castration-resistant prostate cancer. Expand
Transurethral enucleation of the prostate versus transvesical open prostatectomy for large benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials
TLDR
TUEP can be performed effectively and safely with functional outcomes and complications similar to OP for large BPH, whereas it has the advantages of a shorter catheter period, shorter hospital stays and less blood transfusion. Expand
A randomized trial comparing diode laser enucleation of the prostate with plasmakinetic enucleation and resection of the prostate for the treatment of benign prostatic hyperplasia.
TLDR
The efficacy of DiLEP and PKERP were similar for relieving obstruction and low urinary tract symptoms and the downward morcellation technique is more efficient than the resection technique. Expand
Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.
TLDR
It is shown that rotenone induced reactive oxygen species (ROS), leading to apoptotic cell death in PC12 cells and primary neurons, and mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, resulting in caspase-dependent and -independent apoptosis in neuronal cells. Expand
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
TLDR
It is shown that IL-6-activated JAK1 phosphorylates programmed death-ligand 1 (PD-L 1) Tyr112, which recruits the endoplasmic reticulum-associated N-glycosyltransferase STT3A to catalyze PD-L1 glycosylation and maintain PD- L1 stability. Expand
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