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MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation
Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of a variety of proliferative vascular diseases. Recently, we have found that microRNA (miRNA)… Expand
MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?
- Y. Cheng, Ruirui Ji, +5 authors Chunxiang Zhang
- Biology, Medicine
- The American journal of pathology
- 1 June 2007
MicroRNAs (miRNAs) are a recently discovered class of endogenous, small, noncoding RNAs that regulate gene expression. Although miRNAs are highly expressed in the heart, their roles in heart diseases… Expand
Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4.
AIMS The aims of the present study are to determine the miRNA expression signature in rat hearts after ischaemic preconditioning (IP) and to identify an IP-regulated miRNA, miR-21, in IP-mediated… Expand
MicroRNA Expression Signature and the Role of MicroRNA-21 in the Early Phase of Acute Myocardial Infarction*
- Shimin Dong, Y. Cheng, +7 authors Chunxiang Zhang
- Medicine, Biology
- The Journal of Biological Chemistry
- 25 August 2009
Several recent reports have suggested that microRNAs (miRNAs) might play critical roles in acute myocardial infarction (AMI). However, the miRNA expression signature in the early phase of AMI has not… Expand
A translational study of circulating cell-free microRNA-1 in acute myocardial infarction.
miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively stable due to binding… Expand
Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase
Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions. Although its microbicidal functions are well established in vitro, humans… Expand
Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation
- Chunxiang Zhang, D. Baker, +10 authors G. Tigyi
- Medicine, Biology
- The Journal of experimental medicine
- 15 March 2004
Neointimal lesions are characterized by accumulation of cells within the arterial wall and are a prelude to atherosclerotic disease. Here we report that a brief exposure to either alkyl ether analogs… Expand
Effect of sodium selenite, Se-yeast and nano-elemental selenium on growth performance, Se concentration and antioxidant status in growing male goats
Abstract The objective of this experiment was to study the effect of inorganic, organic and elemental nano-selenium on growth performance, Se concentration and antioxidant status in growing male… Expand
miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Exercise induces physiological cardiac growth and protects the heart against pathological remodeling. Recent work suggests exercise also enhances the heart's capacity for repair, which could be… Expand
MicroRNA-21 in Cardiovascular Disease
MicroRNA-21 (miR-21) is a highly expressed microRNA (miRNA) in cardiovascular system. Recent studies have revealed that its expression is deregulated in heart and vasculature under cardiovascular… Expand