• Publications
  • Influence
MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation
TLDR
The results suggest that miRNAs are novel regulatory RNAs for neointimal lesion formation and may be a new therapeutic target for proliferative vascular diseases such as atherosclerosis, postangioplasty restenosis, transplantation arteriopathy, and stroke. Expand
MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation
TLDR
It is demonstrated that miR-145 is a novel VSMC phenotypic marker and modulator that is able of controlling vascular neointimal lesion formation and this finding may have extensive implications for the diagnosis and therapy of a variety of proliferative vascular diseases. Expand
A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia.
TLDR
MiR-221 and miR-222 are novel regulators for VSMC proliferation and neointimal hyperplasia and may also represent promising therapeutic targets in proliferative vascular diseases. Expand
MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?
TLDR
It is demonstrated that miRNAs are aberrantly expressed in hypertrophic mouse hearts, and modulating miR-21 expression via antisense-mediated depletion (knockdown) had a significant negative effect on cardiomyocyte hypertrophy. Expand
Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4.
TLDR
The results suggest that miRNAs are involved in IP-mediated cardiac protection, and an IP-regulated miRNA, miR-21, was one of most upregulated mi RNAs in hearts after IP. Expand
MicroRNA Expression Signature and the Role of MicroRNA-21 in the Early Phase of Acute Myocardial Infarction*
TLDR
It is identified that miR-21 had a protective effect on ischemia-induced cell apoptosis that was associated with its target gene programmed cell death 4 and activator protein 1 pathway and was further confirmed in vivo by decreasedcell apoptosis in the border and infarcted areas of the infarCTed rat hearts after treatment with Ad-miR- 21. Expand
A translational study of circulating cell-free microRNA-1 in acute myocardial infarction.
TLDR
The results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI, and the levels of circulating cell-free miR1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB (creatine kinase-MB) levels. Expand
Cell-specific effects of miR-221/222 in vessels: molecular mechanism and therapeutic application.
TLDR
The results suggest that the biological functions of miR-221/222 in vascular walls are cell-specific and may have important therapeutic applications in many vascular diseases such as atherosclerosis and restenosis after angioplasty. Expand
MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4.
TLDR
Using quantitative real-time RT-PCR, it is demonstrated that microRNA-21 (miR-21) was upregulated in cardiac myocytes after treatment with hydrogen peroxide (H(2)O(2)). Expand
Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase
TLDR
Myeloperoxidase, an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions, can directly modulate vascular inflammatory responses by regulating NO bioavailability during acute inflammation. Expand
...
1
2
3
4
5
...