Chunsheng Huang

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Image indexing and retrieval systems mostly rely on the computation of similarity measures between images. This notion is ill-defined, generally based on simplistic assumptions that do not fit the actual context of use of image retrieval systems. This paper addresses two fundamental issues related to image similarity: checking whether the degree of(More)
The fully glycosylated human omega interferon produced from CHO-SS cells (glycosylated IFN-omega) has been shown to be well-tolerated in man and to induce a sustained virologic response in patients infected with hepatitis C virus (HCV). We examined the antiviral activity of glycosylated IFN-omega and various human IFNs (IFN-alpha, -beta, -gamma and(More)
The synthesis of four l-2'-deoxy-threose nucleoside phosphonates with the natural nucleobases adenine, thymine, cytosine, and guanosine has been performed. Especially the adenine containing analogue (PMDTA) was endowed with potent antiviral activity displaying an EC50 of 4.69 μM against HIV-1 and an EC50 value of 0.5 μM against HBV, whereas completely(More)
The National Chung Hsing University Library has built a digital archive about Taiwan agricultural history. The content is unique in that it covers historical materials about Taiwan during the Japanese colonial period from 1895 to 1945, and that they are all available in full text, in addition to metadata. To make these materials more accessible to the(More)
In an attempt to identify novel nucleoside phosphoramidate analogues for improving the anti-HCV activity of 2'-C-Me-uridine, we have synthesized for the first time a series of l-glutamic acid, l-serine, l-threonine and l-tyrosine containing aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine. Evaluation of their activity against HCV revealed that they(More)
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