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Long noncoding RNA-LET, which is repressed by EZH2, inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell
TLDR
It is found that lncRNA-LET was significantly downregulated in nasopharyngeal carcinoma (NPC) tissues compared with corresponding normal tissues and is transcriptional repressed by EZH2-mediated H3K27 histone methylation on the LET promoter, revealing an epigenetic mechanism for lnc RNA-LET dysregulation.
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[Discussion IL-33 and its receptor ST2 associated with the pathogenesis of allergic rhinitis].
TLDR
IL-33 and its receptor ST2 were highly expressed in the nasal mucosa of patients with AR, suggesting that IL-33/ST2 may play an important role in the pathogenesis of allergic rhinitis.
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MicroRNA-let-7e regulates the progression and development of allergic rhinitis by targeting suppressor of cytokine signaling 4 and activating Janus kinase 1/signal transducer and activator of…
TLDR
MiR-let-7e may serve an important role in the progression and development of AR, while overexpression of miR- let- 7e had an anti-inflammatory effect by targeting SOCS4, which may be achieved by activation of the JAK1/STAT3 signaling pathway.
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CD47 is a Potential Target for the Treatment of Laryngeal Squamous Cell Carcinoma
TLDR
A critical role of CD47 in LSCC development is suggested and the promising treatment of antiCD47/SIRPα and/or CD47siRNA in LS CC is suggested.
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Involvement of T-Helper 9 Activation in a Mouse Model of Allergic Rhinitis
TLDR
AR is related to the changes of cytokines in TH1, TH2, TH9, TH17, and Treg, which are improved by IL-9 silencing, which were ameliorated by IL+AR silencing.
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[Ectopic internal carotid artery presenting as an oropharyngeal mass].
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Thymic stromal lymphopoietin polymorphisms and allergic rhinitis risk: a systematic review and meta-analysis with 6351 cases and 11472 controls.
TLDR
It is demonstrated that TSLP rs1898671 polymorphism was associated with a higher risk for allergic rhinitis.
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[Expression of IL-35, Epstein-Barr virus-induced gene 3 mRNA and IL-12A mRNA in peripheral blood of patients with allergic rhinitis].
TLDR
The decrease of IL-35 and EBI3 mRNA in AR indicated that IL- 35 and EBl3 mRNA may play an important role in allergic rhinitis.
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[Expression of transcription factors T-bet and GATA-3 and relationship to the numbers of eosinophils in rat model of allergic rhinitis].
TLDR
The imbalance of transcription factor GATA-3 and T-bet has a close correlation with the eosinophil count, and may play a key role in the formation of allergic rhinitis.
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Iloprost inhibits acute allergic nasal inflammation by GATA3 -ILC2 pathway in mice
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