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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
A set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes are presented.
Pharmacokinetics and tissue distribution of SU2162, a novel anticancer drug, after intravenous administration in rats
SU2162 is eliminated quickly in the rat and distributes to tissues extensively, and warrants further development as a dosage form for clinical use.
THE PHARMACOKINETICS AND TISSUE DISTRIBUTION OF FATM, A NOVEL ANTITHROMBOTIC AGENT, FOLLOWING ORAL ADMINISTRATION IN RABBITS
It indicated FATM can be absorbed rapidly and concentrate in those organs which well perfuse with blood, showing that it is a promising candidate of the antithrombotic drug for further development.
Determine the Surface Tension of Chinese Herbal Tablet—Siwu Tablet
Objective: Lobes problem could encounter by film coating technology, which will affect the appearance of the coated tablets and, most importantly, will affect the uniformity of the film-coated…
Preparation and Characterization of Two Polymorphs of (3aRS,4RS,7RS,7aSR)-2- (Tricyclo(188.8.131.52 3,7 )decan-1-yl)-4,5,6,7- tetrahydro-4,7-eposyisoindoline-1,3- dione (SU2162) with PXRD and DSC
Objective: To develop the characterization of the polymorphs and the best preparation method of two forms of the title compound (SU2162). After SU2162 was prepared in accordance with the patent…
The Polymorphism and Transformation of (3aRS, 4RS, 7RS, 7aSR)-2-(Tricyclo(184.108.40.206,7)decan-1-yl)-4,5,6,7- tetrahydro-4,7-eposyisoindoline-1,3-dione (SU2162)—A Novel Anticancer Compound
Objective: To determine the transformation between two known crystal forms of the title compound (C18H23NO3, Mr = 301.37). Methods: To recrystallize or heat the crystals and determine the crystal…
THE PHARMACOKINETICS STUDY OF TRANSCRANIAL ADMINISTRATION OF AMILORIDE HYDROCHLORIDE
The data indicated that Amiloride hydrochloride could penetrate into the brain for the treatment of brain diseases by transcranial administration.