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Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia-reperfusion injury in rats via regulating the inflammation response.
TLDR
It is revealed that the administration of fucoidan could regulate the inflammation response via HMGB1 and NF-κB inactivation in I/R-induced myocardial damage. Expand
Neuroprotective Effect of Fucoidan on H2O2-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway
TLDR
Results showed that fucoidan inhibited the decrease of cell viability, scavenged ROS formation and reduced lactate dehydrogenase release in H2O2-induced PC12 cells, and might protect the neurocytes against H1N1-induced apoptosis via reducing ROS levels and activating PI3K/Akt signaling pathway. Expand
Effects of in utero exposure to nanoparticle-rich diesel exhaust on testicular function in immature male rats.
TLDR
It is suggested that prenatal exposure to NR-DE or F-DE leads to endocrine disruption after birth and suppresses testicular function in male rats and the nanoparticles in DE did not contribute to the observed reproductive toxicity. Expand
Estrogenic and anti-androgenic activity of nitrophenols in diesel exhaust particles (DEP).
TLDR
Anti-androgenicity is found in all four nitrophenols isolated from diesel exhaust particles (DEP) because these compounds are alkylphenolic derivatives that might mimic hormones. Expand
Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved.
TLDR
Tartrazine extract significantly enhanced active behavioral response to the open field, increased the escape latency in Morris water maze test and decreased the retention latency in step-through tests, which indicated that more extensive assessment of food additives in current use is warranted. Expand
Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of Aβ peptide in rats.
Fucoidan is a complex sulfated polysaccharide, derived from marine brown seaweed. In the present study, we investigated the effects of fucoidan on improving learning and memory impairment in ratsExpand
Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone.
TLDR
Disruption of testosterone biosynthesis by NR-DE exposure may be a mode of action for reproductive toxicity, which may, in part, be regulated by increasing StAR and P450scc expressions via GH signalling. Expand
Expression of Nerve Growth Factor (NGF), and Its Receptors TrkA and p75 in the Reproductive Organs of the Adult Male Rats
TLDR
The results suggest that NGF is an important growth factor in gonadal function of adult male rats. Expand
Estrogenic and anti-androgenic activities of 4-nitrophenol in diesel exhaust particles.
TLDR
The results suggest that diesel exhaust emissions and the degradation of parathion can lead to accumulation of PNP in air, water, and soil and thus could have serious deleterious effects on wildlife and human health. Expand
Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways.
TLDR
The data suggested that sophocarpine exerted anti-inflammatory activity in vitro, and it might attribute to the inhibition of iNOS and COX-2 expressions via down-regulation of the JNK and p38 MAP kinase signal pathways and inhibition of NF-κB activation. Expand
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