Chunlian Jin

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OBJECTIVE To evaluate the use of homologous gene quantitative PCR (HGQ-PCR) as a method for non-invasive diagnosis of Down syndrome and for prevention of the birth of Down syndrome children. METHODS HGQ-PCR, which can directly detect the additional copy of chromosome 21 by comparing simultaneously amplified two highly homologous genes, i.e. the human(More)
AIMS To verify whether dystrophin gene mutations among Chinese patients feature different types and frequencies from other populations. METHODS Multiplex ligation-dependent probe amplification (MLPA) in combination with multiplex PCR (mPCR) and/or short tandem repeat (STR)-based linkage analysis were applied in a large series of Chinese families affected(More)
We describe a concept for circuit protection and fault current limitation in DC power systems based on the use of solid-state power switches. The approach could be useful in the increasingly widespread application of DC power distribution networks. During normal operation the power switch is always “on”. During faults, the gate of the solid-state switch is(More)
BACKGROUND Idiopathic congenital talipes equinovarus (ICTEV) is a congenital limb deformity. Based on extended transmission disequilibrium testing, Gli-Kruppel family member 3 (Gli3) has been identified as a candidate gene for ICTEV. Here, we verify the role of Gli3 in ICTEV development. METHODS Using the rat ICTEV model, we analyzed the differences in(More)
Ratings of transmission paths, typically determined in an offline environment, are static and conservative, leading to underutilization of transmission assets, higher costs of system operation and renewable energy integration, and lower efficiency. With the ever-increasing transmission congestion costs and new challenges from renewable integration,(More)
OBJECTIVE To investigate the feasibility of using immunohistochemical technique to detect the presence of fetal erythroblasts in the maternal circulation for prenatal diagnosis. METHODS Maternal blood was obtained from 30 pregnant women at 8 to 26 weeks of gestation. Nucleated red blood cells (NRBCs) were separated with Percoll using a discontinuous(More)
The collagen, type IX, alpha 1 (COL9A1) gene was previously identified as a candidate gene for idiopathic congenital talipes equinovarus (ICTEV), a congenital lower limb deformity in humans. In the present study, increased expression levels of COL9A1 were identified in the abductor hallucis muscle of ICTEV patients(More)
This paper presents an approach of implementing the dynamic multi-resolution power diode model in the Virtual Test Bed (VTB), a platform for complex system simulation and prototyping. The new model is a combination of the behavioral model and the physical model. The behavioral model is based upon the widely used Shockley equation; its advantages are(More)
BACKGROUND AND OBJECTIVE Duchenne and Becker muscular dystrophies are X-linked diseases caused by mutations in the dystrophin gene, which affect approximately 1 in 3,500 and 1 in 18,000 boys, respectively. The aim of this work was to develop a method to assist the diagnosis and classification of the disease. MATERIALS AND METHODS A large data set of(More)
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