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4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.
TLDR
These findings provide the first evidence that NP promotes apoptosis, autophagy and necrosis simultaneously in SCs and that this process may involve ROS-dependent JNK- and Akt/AMPK/mTOR pathways.
Lactate Utilization Is Regulated by the FadR-Type Regulator LldR in Pseudomonas aeruginosa
TLDR
A motif with a hyphenated dyad symmetry (TGGTCTTACCA) was identified as essential for the binding of LldR to the upstream region of lldP by using site-directed mutagenesis and interfered with the DNA-binding activity of L-Lactate and D-lactate.
Body mass index and risk of lung cancer: Systematic review and dose-response meta-analysis
TLDR
Keeping normal-to-moderate BMI should be prescribed as an evidence-based lifestyle tip for LC prevention in smokers, as quantitative evidence that increasing BMI is a protective factor against LC is provided.
Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways.
TLDR
The data suggest potentially hormetic effects of NP on spermatogenic function and high-dose NP impairs testicular development and function by reducing cell proliferation and inducing apoptosis involving oxidative stress-related p53-Bcl-2/Bax and -Fas/FasL pathways.
4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.
TLDR
The results suggest that NP stimulates Sertoli cell autophagy and inhibits mTOR-p70S6K/4EBP1 activity through AMPK activation, which is the potential mechanism responsible for the regulation of testis function and differentiation following NP exposure.
Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis
TLDR
In conclusion, destruxin A5 may represent an efficacious and more selective inhibitor of PDGF-BB/PDGFR-ββ signaling and was verified using in vitro, ex vivo and in vivo models, in which the extent of liver fibrosis was effectively alleviated.
A new pharmacological effect of levornidazole: Inhibition of NLRP3 inflammasome activation.
TLDR
The widely applied NLRP3 inflammasome-related models of dextran sodium sulfate (DSS)-induced colitis and LPS-induced endotoxin shock are used to confirm the novel pharmacological effect of levornidazole in vivo.
4‐Nonylphenol induces disruption of spermatogenesis associated with oxidative stress‐related apoptosis by targeting p53‐Bcl‐2/Bax‐Fas/FasL signaling
TLDR
Taken together, NP‐induced apoptosis, hormonal deficiencies, and depletion of fructose potentially impairs spermatogenesis and sperm function.
Efficient Production of 2-Oxobutyrate from 2-Hydroxybutyrate by Using Whole Cells of Pseudomonas stutzeri Strain SDM
TLDR
Whole cells of Pseudomonas stutzeri SDM, containing NAD-independent lactate dehydrogenases, effectively converted 2-hydroxybutyrate into 2-oxobutyrate, an important intermediate in the chemical, drug, and food industries.
Genome Sequence of Pseudomonas stutzeri SDM-LAC, a Typical Strain for Studying the Molecular Mechanism of Lactate Utilization
TLDR
A 4.2-Mb assembly of Pseudomonas stutzeri SDM-LAC is presented, and the annotated four adjacent genes form a lactate utilization operon, which could provide further insights into the molecular mechanism of lactate usage.
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