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Synergistic strategies of predominant toxins in snake venoms.
TLDR
The Toxicity Score is among the few quantitative methods to assess synergism and selection of toxins involved in synergistically enhanced toxicity as the targets are important for development of novel antivenoms or inhibitors. Expand
Species Authentication of Common Meat Based on PCR Analysis of the Mitochondrial COI Gene
TLDR
Seven sets of species-specific primer based on a high heterozygous region of mitochondrial cytochrome c oxidase subunit I (COI) gene were proven to have high species specificity and no cross-reactions and unexpected products to different DNA source. Expand
Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development
TLDR
The latest knowledge on the distribution, pathophysiological effects, and inhibitors of svPLA2s are overviewed to elucidate the potential for a novel, wide spectrum antivenom drug targeting sv PLA2s. Expand
Inactivation of Venom PLA2 Alleviates Myonecrosis and Facilitates Muscle Regeneration in Envenomed Mice: A Time Course Observation
TLDR
The findings of the present study suggested that varespladib is an effective antidote that could neutralize D. acutus venom and allow for earlier and improved rehabilitation outcome. Expand
Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation
TLDR
Varespladib may be a potential first-line drug candidate in snakebite envenomation first aid or clinical therapy and down-regulated serum levels of creatine kinase, lactate dehydrogenase isoenzyme 1, aspartate transaminase, and alaninetransaminase indicated the protection to viscera injury. Expand
Investigation of the inhibitory potential of phospholipase A2 inhibitor gamma from Sinonatrix annularis to snake envenomation
TLDR
SaPLI&ggr; has a wide protection effect to local myonecrosis and systemic toxic reaction against snake venom, which may contribute to broad anti‐venom effects. Expand
Orthogonal optimization of prokaryotic expression of a natural snake venom phospholipase A2 inhibitor from Sinonatrix annularis.
TLDR
A His6-PLIγ pET28 fusion expression vector and transformed Escherichia coli BL21 showed a good inhibitory effect of enzymatic activities to venom PLA2 isolated from D. acutus, Naja atra and Agkistrodon halys venom and had a wide anti-hemorrhage activities. Expand
Comprehensively Surveying Structure and Function of RING Domains from Drosophila melanogaster
TLDR
Based on sequence and structural data, SCRs, conserved equivalent residues and features of intermolecular interfaces were extracted, highlighting the presence of a nucleus for RING domain fold and formation of catalytic core in which related residues and regions exhibit preferential evolutionary conservation. Expand
The inhibitory effect of saPLI&ggr;, a snake sourced PLA2 inhibitor on carrageenan‐induced inflammation in mice
TLDR
The results suggested that saPLI&ggr; had effective anti‐inflammatory effects in vivo, and these were produced by blocking mammalian IB, IIA, V and X sPLA2 subtypes. Expand
Contextual Regulation of TGF-β Signaling in Liver Cancer
TLDR
This review summarizes the known regulatory mechanisms of TGF-β signaling in liver cancer, and how they channel, skew and even switch the actions of T GF-β during cancer progression. Expand
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