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New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C*
Background: It is unclear whether microtubule depolymerization by kinesin-13s is coupled with the hydrolysis step of ATP turnover. Results: Mutation of the kinesin-13-specific KVD motif blocks ATPaseExpand
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Kif2C Minimal Functional Domain Has Unusual Nucleotide Binding Properties That Are Adapted to Microtubule Depolymerization*
Background: Kinesin-13 proteins, such as Kif2C, share a conserved motor domain with motile kinesins, but they depolymerize microtubules. Results: Kif2C is mostly ATP-bound, and Kif2C-ATP has a strongExpand
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A Helical Conotoxin from Conus imperialis Has a Novel Cysteine Framework and Defines a New Superfamily*
Background: Cone snail venoms are a rich source of novel peptide toxins. Results: Conus imperialis contains two new toxins that define a new cysteine framework and adopt an uncommon all-helicalExpand
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Kinesin, 30 years later: Recent insights from structural studies
Motile kinesins are motor proteins that move unidirectionally along microtubules as they hydrolyze ATP. They share a conserved motor domain (head) which harbors both the ATP‐ and microtubule‐bindingExpand
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Structural Insights into the Unusually Strong ATPase Activity of the AAA Domain of the Caenorhabditis elegans Fidgetin-like 1 (FIGL-1) Protein*
Background: Little is known about the structure and activity of the FIGL-1 protein, whose homolog fidgetin is involved in various developmental processes in mammals. Results: The CaenorhabditisExpand
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Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-analysis
It has been reported that the single nucleotide polymorphism (SNP) rs1800012 in COL1A1 might be associated with the susceptibility to sports-related tendon and ligament injuries such as ACL injuries,Expand
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Prognostic factors in patients with recurrent hepatocellular carcinoma treated with salvage liver transplantation: a single-center study
Although salvage liver transplantation (LT) has been widely adopted as a treatment for recurrent hepatocellular carcinoma(HCC), candidate selection criteria have not been established. ThisExpand
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[Evaluation of markers associated with primary biliary cirrhosis in a population of anti-mitochondrial antibody-M2-positive individuals].
OBJECTIVE To explore the distribution of the main clinical symptoms and signs of primary biliary cirrhosis (PBC) in a population of individuals with positivity for anti-mitochondrial antibody-M2Expand
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Identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors.
A series of fused ring derivatives of pyrrolidine and imidazolidinone were designed, synthesized, characterized and assayed against the DENV-2 NS2B-NS3 protease and wild-type DENV-2 virus. The linearExpand
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Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
Kinesin-13s are critical microtubule regulators which induce microtubule disassembly in an ATP dependent manner. To clarify their mechanism, we report here the crystal structure of a functionalExpand
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