Chunguang Shan

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Since the majority of hearing impaired patients suffer from the significant loss of sensory hair cells and associated neurons, stem cell-based approaches hold great promise by replacing the damaged tissues in the ears. For instance, stem cells from the spiral ganglion could be isolated and expanded to regenerate neural structures of the inner ear. It is(More)
Positron emission tomography (PET) imaging with [F-18]-fluoro-2-deoxy-D-glucose (18 F-FDG) is extensively applied in clinical practice. However, in animal experiments, the application of clinical PET is difficult, due to limitations in sensitivity and spatial resolution. This study aimed to determine the potential of 18 F-FDG PET with regard to the imaging(More)
OBJECTIVE To investigate the functional mechanism of metadherin (MTDH), hypoxia-inducible factor-1 alpha (HIF-1α) and transketolase-like gene 1 (TKTL1) and their interaction with each other in laryngeal carcinoma development. METHOD Thirty laryngeal carcinoma samples and 20 samples of para-carcinoma tissue were taken from the patients received operation(More)
OBJECTIVE To explore the expression of phospholipase Cgamma-2 (PLCgamma-2), lipoxygenase-12 (12-LOX) and arachidonic acid (AA) in laryngeal squamous cell carcinoma and to study the the relationship between lipid metabolism and laryngeal squamous cell carcinoma. METHOD In 30 cases of carcinoma tissue and peritumoral laryngeal mucosa tissues (confirmed to(More)
OBJECTIVE To investigate the role of Keap1-Nrf2-ARE pathway in laryngeal carcinoma occurrence and development. METHOD Thirty-five laryngeal carcinoma samples and para-carcinoma tissues were taken from the patients who accepted operation treatment in our hospital from Feb 2012 to Sep 2013. The expression levels of Nrf2 and Keap1 were detected in 35 cases(More)
OBJECTIVE To explore the expression and significance of second mitochondria derived activator of caspase (Smac), X-linked inhibitor of apoptosis protein (XIAP)and cysteine containing aspartate specific protease 3 (caspase-3) in the growth, development and carcinogenesis of the nonnasal inverted papilloma (NIP). METHOD Immunohistochemical method was used(More)
OBJECTIVE To explore the expression of Smac(second mitochondria-derived activator of caspase)and survivin on the growth, development, recurrence and carcinogenesis of the sinonasal inverted papilloma(NIP). METHOD Immunohistochemical method was used to detective the expression of Smac and survivin in 10 cases of (nasal cavity mucosae, NM), 45 cases of NIP.(More)
OBJECTIVE The purpose of this study was to investigate the expression of PKM2 and HIF-1α in laryngeal squamous cell carcinoma and to analyze their correlation in laryngeal squamous cell carcinoma. METHOD Total 37 laryngeal carcinoma samples and para-carcinoma tissues were taken from the patients who accepted operation treatment in the Second Hospital of(More)
OBJECTIVE To explore the expression and significance of survivin and proliferating cell nuclear antigen (PCNA) on the occurrence, proliferation, recurrence and carcinogenesis of the sinonasal inverted papilloma (SNIP). METHOD Immunohistochemical method was used to detect the expression of survivin and PCNA in 10 cases of nasal cavity mucosal (NM), 45(More)
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