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—In the present study, we used the Morris water maze (MWM) to evaluate the effect of Rosmarinic acid (RosA) on learning and memory of D-galactose (D-gal) induced aging mice. To study the learning and memory changes characteristic in animal models of aging treated with RosA, a natural phenolic acid. Animal models of aging were established by using D-gal.(More)
OBJECTIVE To analyze the co-production of thrombolytic enzyme and gamma-polyglutamic acid by liquid-culture of Bacillus subtilis SBS. METHODS We used Bacillus subtilis SBS to produce thrombolytic enzyme (BTE) and 7-polyglutamic acid (gamma-PGA) by liquid fermentation. We conducted orthogonal experiments analysis between carbon source and nitrogen source.(More)
The aim is to study the protective effects of Rosmarinic acid (RosA),on age-related behavior in senescent mice induced by consecutive injection of D-galactose (D-gal) and to explore in-brain mechanism of its effects. In the present study, Female BALB/c mice randomly divided into the control group, model group and 3 doses of RosA treatment groups, and the(More)
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