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The availability of techniques for sensitive detection of early stage osteoarthritis is critical for improving patient health. This study illustrates the feasibility of a fiber-optic particle plasmon resonance (FOPPR) sensor with gold nanoparticles on the unclad region of optical fiber probes for analysis of osteoarthritis biomarkers, tumor necrosis(More)
We present the design and experimental verification of a self-referencing dual-channel fiber optic particle plasmon resonance (FOPPR) sensing system for compensation of thermal and bulk-composition effects as well as nonspecific adsorption in real-time biosensing of complex samples. A theoretical model is first proposed and then a systematic experimental(More)
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