OBJECTIVES Aminoglycosides are commonly used antibiotic agents, and they are known to generate free oxygen radicals within the inner ear and to cause vestibulo-cochlear toxicity and permanent damage to the sensory hair cells and neurons. Melatonin, a pineal secretory product, has the properties of being a powerful direct and indirect antioxidant. The aim of… (More)
It is a very active research field to predict protein functions and active sites by protein surface patches. It is especially challengeable to predict the active sites by structural or biochemical characters. We, here, suggest a simple and efficient method, and at this time focus just on our strategy to solve the tough problems.