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B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.
TLDR
This study identifies a major site of B lymphocytes lymph node egress, shows that FTY720 treatment blocks passage through the cortical lymphatic endothelium, and argues against a functional role for S1P chemotaxis in B lymphocyte egress. Expand
Rgs5 Targeting Leads to Chronic Low Blood Pressure and a Lean Body Habitus
TLDR
The results of this study suggest that RGS5 may balance vascular tone by attenuating vasodilatory signaling in vivo in opposition to RGS2, another RGS (regulator of G protein signaling) family member known to inhibit G protein-coupled receptor-mediated vasoconstrictor signaling. Expand
Lymph node B lymphocyte trafficking is constrained by anatomy and highly dependent upon chemoattractant desensitization.
TLDR
How LN anatomy and chemoattractant receptor signaling organize B lymphocyte LN trafficking is shown to show how B cells lost their polarity, down-regulated their S1P1 receptors, and subsequently strongly up- regulated their sensitivity to chemokines. Expand
A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2.
TLDR
A HIF-1 target, Vasn/ATIA (anti-TNFα-induced apoptosis), is described, which protects cells against TNF α- and hypoxia- induced apoptosis through regulating the function of the mitochondrial antioxidant, thioredoxin-2, and ROS generation. Expand
IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa.
TLDR
These findings provide a mechanism for the transient in vivo depletion of circulating T cells after IL-7 administration and suggest that intestinal homing and memory-like conversion of naive T cells are critical steps in theIL-7-driven immunologic reconstitution of lymphopenic hosts. Expand
TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones
TLDR
TLR4 signaling enhances B lymphocyte trafficking into lymph nodes, induces B lymphocytes clustering and interactions within LN follicles, leads to sustained in vivo B cell proliferation, overcomes the restriction that limits the access of nonantigen-activated B cells to germinal center dark zones, and enhances the generation of memory and plasma cells. Expand
Impaired Trafficking of Gnai2+/− and Gnai2−/− T Lymphocytes: Implications for T Cell Movement within Lymph Nodes
TLDR
The importance of Gαi2 for T lymphocyte chemokine receptor signaling is demonstrated and it is argued that local chemoattractants regulate the movement of CD4 T cells in lymph nodes. Expand
Interleukin-6 protects MIN6 beta cells from cytokine-induced apoptosis.
TLDR
Data indicate that cytokine-induced cell death in the MIN6 beta cell line involves mechanisms that are, in part, NF-kappaB- and NO-dependent, as well as IL-6 and N-monomethyl-l-arginine. Expand
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing
TLDR
In vivo treatment with an antibody to the gut-homing integrin α4β7 was shown to reduce viral transmission, delay disease progression, and induce persistent virus control in macaques challenged with simian immunodeficiency virus (SIV). Expand
Chemoattract receptor signaling and its role in lymphocyte motility and trafficking.
TLDR
The contributions of in vivo imaging of lymphocytes from various mouse mutants to the understanding of the roles chemoattractants play in lymphocyte entrance into and exit from lymph nodes, and in coordinating and facilitating the movements of lymphocyte within lymph nodes are focused on. Expand
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