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Multilevel-cell (MLC) storage is a typical way for achieving increased capacity and thus lower cost-per-bit in memory technologies. In phase-change memory (PCM), however, MLC storage is seriously hampered by the phenomenon of resistance drift. Reference cells may be used to offer some relief, however their effectiveness is limited due to the stochastic(More)
  • Chung Lam
  • 2008 International Symposium on VLSI Technology…
  • 2008
The ultimate goal of emerging memory technology researchers and developers is to devise a universal memory to replace all memories in complex hierarchies of memory systems in modern computers. These memory hierarchies are designed to bridge the performance gap between the central processing units and the memories while keeping the cost down. This paper(More)
OBJECTIVE We wished to develop a highly selective positron emission tomography (PET) imaging agent targeting PHF-tau in human Alzheimer's disease (AD) brains. METHODS To screen potential tau binders, human AD brain sections were used as a source of native paired helical filament (PHF)-tau and Aβ rather than synthetic tau aggregates or Aβ fibrils generated(More)
Recent advances in neuroscience together with nanoscale electronic device technology have resulted in huge interests in realizing brain-like computing hardwares using emerging nanoscale memory devices as synaptic elements. Although there has been experimental work that demonstrated the operation of nanoscale synaptic element at the single device level,(More)
Phase-change memory (PCM) has emerged in recent years as the most promising technology for non-volatile memory due to its very high throughput performance and read/write endurance as well as future scalability. Multilevel functionality is crucial for increasing the capacity and thus enhancing the cost per GByte competitiveness of the PCM technology.(More)
Phase change memory (PCM) is a non-volatile solid-state memory technology based on the large resistivity contrast between the amorphous and crystalline states in phase change materials. We present the physics behind this large resistivity contrast and describe how it is being exploited to create high density PCM. We address the challenges facing this(More)
Senile plaques and neurofibrillary tangles are prominent neuropathological hallmarks in Alzheimer's disease and are considered to be targets for therapeutic intervention as well as biomarkers for diagnostic in vivo imaging agents. While there are a number of amyloid-β positron emission tomography (PET) tracers currently in different stages of clinical(More)
Degradation of 11 pyrethroids was measured over approximately 100 days in three sediment/water systems under aerobic and anaerobic conditions at 25 °C in the dark. The three California sediments represented a range of textures and organic matter. Test compounds were bifenthrin, cypermethrin, ζ-cypermethrin, cyfluthrin, β-cyfluthrin, deltamethrin,(More)
The computational performance of the biological brain has long attracted significant interest and has led to inspirations in operating principles, algorithms, and architectures for computing and signal processing. In this work, we focus on hardware implementation of brain-like learning in a brain-inspired architecture. We demonstrate, in hardware, that 2-D(More)