Share This Author
Direct regulation of TWIST by HIF-1α promotes metastasis
Evidence is provided of a key signalling pathway involving HIF-1α and TWIST that promotes metastasis in response to intratumoural hypoxia that promotes epithelial–mesenchymal transition and metastastic phenotypes.
Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma
The enriched OC-SLC possesses the characteristics of both stem cells and malignant tumors and expression of stemness markers (Nanog/Oct-4/CD133) contradicts the survival prognosis of OSCC patients.
miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma.
The findings suggest that miR-31 contributes to the development of HNSCC by impeding FIH to activate HIF under normoxic conditions.
miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes
This study shows that miR-146a expression contributes to oral carcinogenesis by targeting the IRAK1, TRAF6 and NUMB genes.
miR-196a Overexpression and miR-196a2 Gene Polymorphism Are Prognostic Predictors of Oral Carcinomas
- Chung-Ji Liu, Meng-Miao Tsai, H. Tu, Man-tin Lui, Hui‐Wen Cheng, Shu-Chun Lin
- Medicine, BiologyAnnals of Surgical Oncology
- 1 December 2013
Multivariate analysis showed that both high miR-196a expression and TT genotype were independent predictors for poor survival in OSCC, and the risk of mortality was greatest for patients with highMiR- 196a level and positive node status.
Exploiting salivary miR‐31 as a clinical biomarker of oral squamous cell carcinoma
- Chung-Ji Liu, Shu-Chun Lin, Cheng-Chieh Yang, Hui‐Wen Cheng, Kuo-Wei Chang
- Medicine, BiologyHead & neck
- 1 February 2012
MiRNA‐31 (miR‐31) is significantly upregulated in oral carcinoma tissues and plays oncogenic roles in Oral carcinogenesis.
miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis.
The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers.
Together, these findings reveal a crucial role for S100A4 signaling pathways in maintaining the stemness properties and tumorigenicity of HN-CICs and suggest that targeting S100a4 signaling may offer a new targeted strategy for HNSCC treatment by eliminating HN.
Association of Expression Aberrances and Genetic Polymorphisms of Lysyl Oxidase with Areca-Associated Oral Tumorigenesis
- Tzong-Ming Shieh, Shu-Chun Lin, Chung-Ji Liu, Shu-Shin Chang, Tiedjen Ku, Kuo-Wei Chang
- BiologyClinical Cancer Research
- 1 August 2007
LOX exerts oncogenic roles in areca-associated OSCC, and this potential could be affected by the existence of LOX propeptide domain or genetic polymorphism.
miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.
- Cheng-Chieh Yang, P. Hung, Shu-Chun Lin
- Medicine, BiologyJournal of oral pathology & medicine : official…
- 1 May 2011
Functional assays revealed ectopically over-expressed miR-181 would enhance cell migration and invasion, but not the ability of anchorage-independent growth of OSCC cells, which could potentially be exploited as a putative biomarker for patients with OSCC.