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Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death
Severe side effects are major problems with chemotherapy of gastric cancer (GC). These side effects can be reduced by using sensitizing agents in combination with therapeutic drugs. In this study,Expand
DNA Polymerases as targets for gene therapy of hepatocellular carcinoma
BackgroundHepatocyte carcinoma (HCC) is one of the most common malignancies worldwide. Despite many achievements in diagnosis and treatment, HCC mortality remains high due to the malignant nature ofExpand
ERα36 is an effective target of epigallocatechin-3-gallate in hepatocellular carcinoma.
Epigallocatechin-3-gallate (EGCG) is a natural product with potential anti-cancer property whose direct target has not been identified. This study intended to investigate ERα36, a new isoform ofExpand
A novel multikinase inhibitor R8 exhibits potent inhibition on cancer cells through both apoptosis and autophagic cell death
Chemotherapy is an important treatment for cancer patients, especially for those with unresectable lesions. Targeted therapy of cancer by specific inhibition of aberrant tyrosine kinase activities inExpand
Characterization of Genetic Polymorphism of Glycine N-Methyltransferase Gene in Hepatocellular Carcinoma
Previously, we reported that glycine N-methyltransferase (GNMT) expression levels were diminished in human liver cancer. Herein, the polymorphisms of GNMT in 5 hepatocellular carcinoma (HCC) and 2Expand
Effective inhibition of cancer cells by recombinant adenovirus expressing EGFR-targeting artificial microRNA and reversed-caspase-3
The EGFR-targeting cancer therapies are commonly facing drug resistance, mostly due to mutations. Gene therapy with artificial microRNA targeting EGFR conserved sequence may avoid such problem. InExpand
[Downregulation of proteinase activated receptor 4 inhibits migration of SW620 human colorectal cancer cells].
OBJECTIVE To establish the human colorectal cancer cell model SW620/PAR4D with inducible suppression of proteinase activated receptor 4 (PAR4) expression, and investigate the role PAR4 plays in theExpand
[Construction, expression and purification of a mammalian secretory recombinant fusion protein rPC].
Drugs targeting immune checkpoint are used for cancer treatment, but resistance to single drug may occur. Combination therapy blocking multiple checkpoints simultaneously can improve clinicalExpand