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l-3-n-Butylphthalide attenuates β-amyloid-induced toxicity in neuroblastoma SH-SY5Y cells through regulating mitochondrion-mediated apoptosis and MAPK signaling
Alzheimer's disease (AD) is a progressive neurodegenerative disease. Amyloid-β protein (Aβ), the hallmark of AD, invokes a cascade of mitochondrial dysfunction and eventually leads to neuronal death.Expand
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L-3-n-Butylphthalide attenuates neuroinflammatory responses by downregulating JNK activation and upregulating Heme oxygenase-1 in lipopolysaccharide-treated mice
Abstract Microglia activation-induced neuroinflammation contributes to neuronal damage in neurodegenerative diseases. Inhibition of microglia activation and reduction of major neurotoxic cytokinesExpand
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[Studies on chemical constituents from leaves of Sapium sebiferum].
OBJECTIVE To study the chemical constituents from leaves of Sapium sebiferum. METHOD The compounds were isolated and purified by silic gel column chromatography and preparative HPLC. The structuresExpand
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Glomerxanthones A-C, three xanthonolignoid C-glycosides from Polygala glomerata Lour.
Three novel xanthonolignoid C-glycosides, glomexanthones A-C, with a trans-dihydrobenzofuran on B ring and a 2-hydroxymethyl-5-hydroxyl-2-pentenoic acid moiety in the sugar chain were isolated fromExpand
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[Role of DNA-associated autoantibodies to cell membrane in the diagnosis of juvenile systemic lupus erythematosus].
OBJECTIVE To establish a method of indirect immunofluorescence (IIF) to measure DNA (mDNA)-associated autoantibodies to cell membrane, and to evaluate diagnostic value of the anti-mDNA antibodies inExpand
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Directed Copper-Catalyzed Intermolecular Aminative Difunctionalization of Unactivated Alkenes.
  • Y. Li, Y. Liang, +7 authors Junkai Fu
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 10 October 2019
A diverse collection of copper-catalyzed intermolecular aminative difunctionalizations of unactivated alkenes with N-halodialkylamines as the terminal dialkylamino source is reported. A bidentateExpand
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The novel inhibitory effect of Pangdahai on fatty acid synthase
Recently, animal fatty acid synthase (FASN) is reported as a potential therapeutic target for obesity and cancer. Considerable interest has been developed in searching for novel inhibitors of thisExpand
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Synthesis of β-acetoxy alcohols by PhI(OAc)2-mediated metal-free diastereoselective β-acetoxylation of alcohols.
β-Acetoxy alcohols can be synthesized in good yields with excellent diastereoselectivity from tertiary alcohols through PhI(OAc)2-mediated metal-free β-acetoxylation. Mechanistic studies showed thatExpand
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[Role of Nrf2 in neurodegenerative diseases and recent progress of its activators].
The nuclear factor erythroid 2 related factor 2 (Nrf2) is a key protein of endogenous antioxidant defense systems in the body. In response to oxidative stress, Nrf2 translocates to nucleus and bindsExpand
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